Identification of the most appropriate therapeutic target for PNH

确定 PNH 最合适的治疗靶点

• 批准号: 19K08862
• 负责人: Ueda Yasutaka
• 金额: $ 2.75万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K08862/
• 关键词: 発作性夜間ヘモグロビン尿症; PNH; 溶血性貧血; 抗補体薬; 血管内溶血; 血管外溶血; プロペルジン; 補体; 補体疾患

项目成果

Effectiveness of eculizumab treatment in patients aged >65 years with paroxysmal nocturnal hemoglobinuria (PNH): results from the International PNH Registry

依库丽单抗治疗年龄 >65 岁阵发性睡眠性血红蛋白尿 (PNH) 患者的有效性：国际 PNH 登记处的结果

• 发表时间: 2020
• 作者: Jong Wook Lee;Yasutaka Ueda;Philippe Gustovic;Ke Zu;Alexander Kulagin;Morag Griffin
• 通讯作者: Morag Griffin

Cold Agglutinin Disease (CAD) Real-World Evidence (CADENCE) Registry: Design of the First International, Prospective CAD Registry

冷凝集素病 (CAD) 真实世界证据 (CADENCE) 注册中心：第一个国际前瞻性 CAD 注册中心的设计

• 发表时间: 2020
• 作者: Alexander Roth;Ulrich Jaeger;Bernd Jilma;Wilma Barcellini;Anita Hill;Quentin Hill;David J. Kuter;Catherine M. Broome;Marc Michel;Sacha Sergio Zeerleder;Yasutaka Ueda;Jaime Morales-Arias;Jun Su and Sjgbjorn Berentsen
• 通讯作者: Jun Su and Sjgbjorn Berentsen

Clinical Significance of Small PNH-Type Cell Populations in Bone Marrow Failure Syndromes - an Interim Analysis of Japanese Multicentrer Prospective Study -

小 PNH 型细胞群在骨髓衰竭综合征中的临床意义 - 日本多中心前瞻性研究的中期分析 -

• 发表时间: 2021
• 作者: Yasutaka Ueda;Kohei Hosokawa;Ken Ishiyama;Hiroyuki Takamori;Yuji Yonemura;Naoshi Obara;Hideyoshi Noji;Kiyoshi Ando;Tsutomu Shichishima;Takayuki Ikezoe;Shigeru Chiba;Haruhiko Ninomiya;Tatsuya Kawaguchi;Jun-ichi Nishimura;Yuzuru Kanakura; Shi
• 通讯作者: Shi

THE RELATIONSHIP BETWEEN THE PRETREATMENT PNH CLONE SIZE AND CLINICAL COURSE IN PATIENTS WITH BONE MARROW FAILURE SYNDROMES: INTERIM ANALYSIS OF JAPANESE MULTICENTER PROSPECTIVE STUDY

骨髓衰竭综合征患者治疗前 PNH 克隆大小与临床病程之间的关系：日本多中心前瞻性研究的中期分析

• 发表时间: 2019
• 作者: Yasutaka Ueda;Kohei Hosokawa;Ken Ishiyama;Hiroyuki Takamori;Yuji Yonemura;Naoshi Obara;Hideyoshi Noji;Hiroshi Takahashi;Yukari Shirasugi;Takahisa Matsuda;Kiyoshi Ando;Tsutomu Shichishima;Takayuki Ikezoe;Shigeru Chiba;Haruhiko Ninomiya;Tatsu
• 通讯作者: Tatsu

Donor stem cell‐derived paroxysmal nocturnal hemoglobinuria after umbilical cord blood transplantation

脐带血移植后供体干细胞源性阵发性睡眠性血红蛋白尿

• DOI: 10.1111/ejh.13498
• 发表时间: 2020
• 期刊: European Journal of Haematology
• 影响因子: 3.1
• 作者: Nakaya Yosuke;Nakao Takafumi;Ueda Yasutaka;Takamori Hiroyuki;Nishimura Jun‐Ichi;Tatsumi Naoko;Tsutsumi Minako;Yoshida Masahiro;Yoshimura Takuro;Hayashi Yoshiki;Yamane Takahisa
• 通讯作者: Yamane Takahisa