The photopic negative response as a biomarker for functional integrity of the optic nerve

明视阴性反应作为视神经功能完整性的生物标志物

• 批准号: 34425406
• 负责人: Professor Dr. Jan Kremers, Ph.D.
• 金额: --
• 依托单位: Augenklinik
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2007
• 资助国家: 德国
• 起止时间: 2006-12-31 至 2013-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/34425406?language=en
• 关键词: photopic; negative; response; biomarker; functional

In the first period of the project, the photopic negative response (PhNR) has been studied using different techniques. These techniques aimed at optimizing the signal-to-noise ratio of the PhNR and at elucidating cone driven signals in the pathways leading to a PhNR. The data have been used to perform experiments with normal subjects and glaucoma patients. The results indicate that the PhNR is a potential biomarker for glaucoma when using optimal stimulus conditions. In addition, a stimulus paradigm has been used in the lab Erlangen and in Freiburg to be able to compare the results obtained in the two labs.The goal of the work will be a full description of the ERG components and the stimulus conditions that are optimal for diagnosis and monitoring of glaucoma. A full comparative study between normal subjects and glaucoma patients using these conditions will be performed. A comparison with the pattern ERG in identical individuals is planned. A comparison of the outcome of the measurements performed in Freiburg and in Erlangen will be performed. An additional goal of work in the requested year. Finally, the electrophysiological data will be compared with structural data (OCT, HRT; GDx) from the same individuals.

在项目的第一阶段，使用不同的技术研究了明视负反应（PhNR）。这些技术旨在优化PhNR的信噪比，并阐明导致PhNR的途径中的锥体驱动信号。这些数据已被用于对正常受试者和青光眼患者进行实验。结果表明，当使用最佳刺激条件时，PhNR是青光眼的潜在生物标志物。此外，埃尔兰根实验室和弗赖堡实验室还使用了刺激范例，以便能够比较两个实验室获得的结果。这项工作的目标将是对诊断和监测青光眼的最佳ERG成分和刺激条件进行全面描述。将使用这些条件在正常受试者和青光眼患者之间进行全面的比较研究。计划与相同个体的模式ERG进行比较。将对在弗赖堡和埃尔兰根进行的测量结果进行比较。请求年份的额外工作目标。最后，将电生理数据与来自相同个体的结构数据（OCT、HRT; GDx）进行比较。

项目成果

On- and off-response ERGs elicited by sawtooth stimuli in normal subjects and glaucoma patients

• DOI: 10.1007/s10633-012-9323-4
• 发表时间: 2012-06-01
• 期刊: DOCUMENTA OPHTHALMOLOGICA
• 影响因子: 1.4
• 作者: Pangeni, Gobinda;Laemmer, Robert;Kremers, Jan
• 通讯作者: Kremers, Jan

Spectral characteristics of the PhNR in the full-field flash electroretinogram of normals and glaucoma patients

• DOI: 10.1007/s10633-011-9304-z
• 发表时间: 2012-04-01
• 期刊: DOCUMENTA OPHTHALMOLOGICA
• 影响因子: 1.4
• 作者: Kremers, Jan;Jertila, Mounira;Horn, Folkert K.
• 通讯作者: Horn, Folkert K.