Enabling Technologies for Motion Corrected Positron Emission Tomography (PET) of Unanaesthetized Laboratory Animals

未麻醉实验动物运动校正正电子发射断层扫描 (PET) 的实现技术

• 批准号: DP0663519
• 负责人: Prof Roger Fulton
• 金额: $ 28.23万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-05-08 至 2009-12-14
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0663519
• 关键词: Enabling; Technologies; Motion; Corrected; Positron

Small animal molecular imaging is a powerful tool in biological research and drug discovery. Anaesthesia is routinely used to avoid motion distortion, but can profoundly alter the biological process studied. This research will enable quantitative imaging of neurobiological phenomena in awake laboratory animals. It will create new opportunities for Australian basic researchers to use innovative technology with expected high economic potential, and benefit small biotech companies by facilitating pre-clinical and clinical development of new pharmaceuticals. The new motion tracking and image reconstruction technologies developed will strengthen Australia's leading position in engineering and biomedical systems development.

小动物分子成像是生物研究和药物发现的强大工具。麻醉通常用于避免运动扭曲，但可以深刻地改变所研究的生物过程。 这项研究将能够对清醒实验动物的神经生物学现象进行定量成像。它将为澳大利亚基础研究人员创造新的机会，利用具有预期高经济潜力的创新技术，并通过促进新药的临床前和临床开发使小型生物技术公司受益。开发的新运动跟踪和图像重建技术将加强澳大利亚在工程和生物医学系统开发方面的领先地位。