A feasibility study of novel technologies to minimize motion-induced biases in functional and structural MRI of young, opioid-affected cohorts

一项新技术的可行性研究，旨在最大限度地减少受阿片类药物影响的年轻群体的功能和结构 MRI 中运动引起的偏差

基本信息

批准号：
10020594
负责人：
Allyson Patricia Mackey
金额：
$ 27.34万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-30 至 2021-03-31
项目状态：
已结题

项目摘要

PROJECT SUMMARY Opioid exposure, both prenatally and in early childhood, is associated with elevated risk for attention deficit hyperactivity disorder (ADHD), anxiety, low academic performance, and poor health. A major knowledge gap exists in understanding how opioid exposure impacts early brain development, giving rise to risk for adverse developmental outcomes. Neuroimaging studies in young children, ages 3-5, offer an opportunity to quantify developmental processes that are likely implicated in the differing trajectories of opioid-exposed children compared to their non-exposed peers. Unfortunately, the accuracy and reliability of neuroimaging methods in this cohort are not well-established. It is now well known that both structural and functional neuroimaging measures are prone to errors induced by subject motion. Moreover, it is known that many of the comorbid features of opioid exposure are likely to increase children’s in-scanner motion. This is on top of the existing challenges in achieving compliance for imaging studies with healthy, awake children in this age range. In total, this raises substantial concern that existing neuroimaging methods are not sufficiently motion-robust to be used in studies of children ages 3-5. We propose to address these concerns with a feasibility study, comparing the existing methods developed for the Adolescent Brain Cognitive Development (ABCD) study with novel methods we will develop and optimize for young children. We will evaluate our methods in a sample of 100 children, ages 3-5, recruited from the community in Philadelphia that has been hardest hit by the opioid crisis. We will test whether our novel technologies improve the quality of the raw imaging data, and reduce motion biases in the derived morphometric and functional measures. By collecting a broad set of measures on children’s environments (family drug use, family mental health, stress, social support), cognition, and mental health, we will determine predictors of successful imaging in order to inform sampling strategies in future studies of opioid exposure and brain development. Children whose data is more likely to be unusable will need to be oversampled, or statistically up-weighted, to ensure they are appropriately represented in the final sample. Preliminary data will also generate effect sizes for links between opioid exposure and neurocognitive development to inform decisions about imaging sample sizes in future studies. In sum, the primary outcomes of this work will be novel, validated structural and functional neuroimaging imaging methods for young children, and critical feasibility data to inform the design of future large-scale multi-center studies addressing developmental questions, particularly those related to opioid exposure.

项目摘要在产前和幼儿时期，阿片类药物暴露与注意力不足的风险升高有关多动症障碍（ADHD），动画，学业表现较低和健康状况不佳。一个主要的知识差距存在于了解阿片类药物暴露如何影响早期大脑发育，从而引起广告的风险发展结果。 3-5岁的幼儿的神经影像学研究提供了量化的机会在暴露于阿片类药物的儿童的差异轨迹中可能实施的发展过程与他们的非暴露同龄人相比。不幸的是，该队列中神经影像学方法的准确性和可靠性尚不确定。这是现在众所周知，结构和功能性神经影像学措施都容易受试者引起的错误运动。此外，众所周知，阿片类药物暴露的许多合并特征可能会增加儿童的扫描仪运动。这是实现成像研究合规性的现有挑战在这个年龄范围内健康，清醒的孩子。总的来说，这引起了人们对现有神经影像的实质关注方法不足以进行运动，无法在3-5岁儿童的研究中使用。我们建议通过可行性研究来解决这些问题，并比较为青少年的大脑认知发展（ABCD）研究，我们将开发并优化针对年幼的孩子。我们将评估我们从社区招募的100名3-5岁儿童的样本中的方法在费城，阿片类药物危机受到最大打击。我们将测试我们的新技术是否有所改善原始成像数据的质量，并减少派生形态和功能的运动偏差措施。通过收集有关儿童环境的广泛措施（家庭吸毒，家庭精神健康，压力，社会支持），认知和心理健康，我们将确定成功成像的预测指标为了为未来的阿片类药物暴露和大脑发育的研究提供抽样策略。孩子们数据更可能需要过度采样或统计上的加权，以确保它们是在最终样本中适当表示。初步数据还将为链接生成效应大小 Opioid暴露和神经认知发展，以告知有关将来成像样本大小的决策研究。总而言之，这项工作的主要结果将是新颖的，经过验证的结构和功能性神经影像学成像幼儿的方法以及关键的可行性数据，以告知未来大规模多中心的设计研究解决发展问题的研究，尤其是与阿片类药物暴露有关的问题。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Environmental influences on the pace of brain development.

DOI：
10.1038/s41583-021-00457-5
发表时间：
2021-06
期刊：
Nature reviews. Neuroscience
影响因子：
0
作者：
Tooley UA;Bassett DS;Mackey AP
通讯作者：
Mackey AP

Individual differences in T1w/T2w ratio development during childhood.

DOI：
10.1016/j.dcn.2023.101270
发表时间：
2023-08
期刊：
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
影响因子：
4.7
作者：
Boroshok, Austin L.;McDermott, Cassidy L.;Fotiadis, Panagiotis;Park, Anne T.;Tooley, Ursula A.;Gatavins, Martins M.;Tisdall, M. Dylan;Bassett, Dani S.;Mackey, Allyson P.
通讯作者：
Mackey, Allyson P.

Developmental Correlates of Accelerated Molar Eruption in Early Childhood.