3D printed drug delivery systems with the ability of time controlled drug release

具有时间控制药物释放能力的3D打印药物输送系统

• 批准号: 355927747
• 负责人: Professor Dr.-Ing. Hermann Seitz
• 金额: --
• 依托单位: Institut für Biomedizinische Technik
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/355927747?language=en
• 关键词: 3D; printed; drug; delivery; systems

The aim of this project is the development of a drug delivery system (DDS) with the ability of timecontrolled drug release. The DDS shall be manufactured via a photo-polymerizing 3D printing process, which enables the selective local immobilization of several model drugs by covalent binding using photo-curable crosslinkers. The 3D printing process is based on a microstereolithographic process for the creation of a base body, and inkjet printing for the local positioning of drug depots. The crosslinking between drugs and the base body provides the opportunity to improve the control of drug release. In this regard, the cleavage of the covalent crosslinker bonds shall be utilized. The advantages of the new DDS compared to current medical applications are: - drug release of several drugs, - local selective crosslinking between drugs and the base body, - retarded drug release via cleavage of covalent bonds, - defined release time points and release periods (multi-mode release) and - creation of local drug gradients. Furthermore, the new 3D printing process provides widespread opportunities for the development of novel combination products in medicine, as well as for the preparation of scaffold structures for tissue engineering.

本课题的目的是研制一种具有时间控制释药能力的给药系统。DDS应通过光聚合3D打印工艺制造，该工艺可通过使用光固化交联剂的共价结合选择性局部固定几种模型药物。3D打印工艺基于用于创建基体的微立体光刻工艺，以及用于药物仓库局部定位的喷墨打印。药物和基体之间的交联提供了改善药物释放控制的机会。在这方面，应利用共价交联剂键的裂解。与目前的医疗应用相比，新DDS的优点是：-几种药物的药物释放，-药物和基体之间的局部选择性交联，-通过共价键的裂解延迟药物释放，-限定的释放时间点和释放周期（多模式释放）和-产生局部药物梯度。此外，新的3D打印工艺为医学中新型组合产品的开发以及组织工程支架结构的制备提供了广泛的机会。

项目成果

Novel 3D printing concept for the fabrication of time-controlled drug delivery systems

• DOI: 10.1515/cdbme-2018-0035
• 发表时间: 2018-09
• 期刊: Current Directions in Biomedical Engineering
• 作者: J. Konasch;Alexander Riess;M. Teske;Natalia Rekowska;R. Mau;T. Eickner;N. Grabow;H. Seitz

Thermomechanical properties of PEGDA and its co-polymers

• DOI: 10.1515/cdbme-2018-0161
• 发表时间: 2018-09
• 期刊: Current Directions in Biomedical Engineering
• 作者: Natalia Rekowska;D. Arbeiter;J. Konasch;Alexander Riess;R. Mau;T. Eickner;H. Seitz;N. Grabow;M. Teske

A Novel Hybrid Additive Manufacturing Process for Drug Delivery Systems with Locally Incorporated Drug Depots

• DOI: 10.3390/pharmaceutics11120661
• 发表时间: 2019-12-01
• 期刊: PHARMACEUTICS
• 影响因子: 5.4
• 作者: Konasch, Jan;Riess, Alexander;Seitz, Hermann
• 通讯作者: Seitz, Hermann

3D-printed PEGDA structure with multiple depots for advanced drug delivery systems

3D 打印 PEGDA 结构，具有多个用于先进药物输送系统的储存库

• DOI: 10.18416/ammm.2019.1909s09t03
• 发表时间: 2019
• 作者: Konasch;Rekowska;Eickner;Grabow
• 通讯作者: Grabow

Thermomechanical properties of PEGDA in combination with different photo-curable comonomers

PEGDA与不同光固化共聚单体组合的热机械性能

• DOI: 10.1515/cdbme-2019-0080
• 发表时间: 2019
• 期刊: Current Directions in Biomedical Engineering
• 作者: Rekowska;Arbeiter;Konasch;Eickner;Grabow
• 通讯作者: Grabow