3D printed drug delivery systems with the ability of time controlled drug release

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The aim of this project is the development of a drug delivery system (DDS) with the ability of timecontrolled drug release. The DDS shall be manufactured via a photo-polymerizing 3D printing process, which enables the selective local immobilization of several model drugs by covalent binding using photo-curable crosslinkers. The 3D printing process is based on a microstereolithographic process for the creation of a base body, and inkjet printing for the local positioning of drug depots. The crosslinking between drugs and the base body provides the opportunity to improve the control of drug release. In this regard, the cleavage of the covalent crosslinker bonds shall be utilized. The advantages of the new DDS compared to current medical applications are: - drug release of several drugs, - local selective crosslinking between drugs and the base body, - retarded drug release via cleavage of covalent bonds, - defined release time points and release periods (multi-mode release) and - creation of local drug gradients. Furthermore, the new 3D printing process provides widespread opportunities for the development of novel combination products in medicine, as well as for the preparation of scaffold structures for tissue engineering.