3D printed drug delivery systems with the ability of time controlled drug release

本项目的目的是开发一种具有时间控制药物释放能力的药物传递系统(DDS)。DDS应通过光聚合3D打印工艺制造，该工艺能够通过使用光固化交联剂的共价结合来选择性地局部固定几种模型药物。3D打印工艺基于微立体平版印刷工艺，用于创建基质，以及喷墨打印，用于药库的局部定位。药物与骨架之间的交联为提高药物释放控制提供了机会。在这方面，应利用共价交联键的裂解。与目前的医疗应用相比，新的DDS的优点是：-几种药物的药物释放，-药物和基质之间的局部选择性交联，-通过共价键的裂解延缓药物释放，-限定的释放时间点和释放周期(多模式释放)以及-产生局部药物梯度。此外，新的3D打印工艺为医学上新的组合产品的开发以及组织工程支架结构的制备提供了广泛的机会。

The aim of this project is the development of a drug delivery system (DDS) with the ability of timecontrolled drug release. The DDS shall be manufactured via a photo-polymerizing 3D printing process, which enables the selective local immobilization of several model drugs by covalent binding using photo-curable crosslinkers. The 3D printing process is based on a microstereolithographic process for the creation of a base body, and inkjet printing for the local positioning of drug depots. The crosslinking between drugs and the base body provides the opportunity to improve the control of drug release. In this regard, the cleavage of the covalent crosslinker bonds shall be utilized. The advantages of the new DDS compared to current medical applications are: - drug release of several drugs, - local selective crosslinking between drugs and the base body, - retarded drug release via cleavage of covalent bonds, - defined release time points and release periods (multi-mode release) and - creation of local drug gradients. Furthermore, the new 3D printing process provides widespread opportunities for the development of novel combination products in medicine, as well as for the preparation of scaffold structures for tissue engineering.