INTEGRATED ANALYSIS OF STEM CELL FUNCTION IN PLANT GROWTH AND DEVELOPMENT (ERA-PG 059)

植物生长发育中干细胞功能的综合分析 (ERA-PG 059)

• 批准号: 35981522
• 负责人: Professor Dr. Thomas Laux
• 金额: --
• 依托单位: Institut für Biologie III
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2007
• 资助国家: 德国
• 起止时间: 2006-12-31 至 2011-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/35981522?language=en
• 关键词: INTEGRATED; ANALYSIS; STEM; CELL; FUNCTION

Stem cells are essential to the growth and development of plants and provide the ultimate origin of all agriculture and forestry. Although some key genes required for the establishment and maintenance of stem cells are identified, we lack information on the networks governing cell differentiation and cell cycle of different stem cell populations, on how these mechanisms determine common and specific behaviors of the different stem cell groups and how they integrate stem cell activity with changing environmental conditions. This proposal integrates the work of world-leading labs that perform key research on stem cell populations of the shoot, root and vascular meristems, cell cycle control, growth modeling and image analysis. Europe has a global lead in plant stem cell research and cell division control, and this proposal will integrate the research of the different labs involved, creating new synergies and substantial added value. New tools and strategies combining genomics, reverse genetics, smart genetic screens, and novel cell biology will be exploited to address the key issue of how specification of stem cell regions by transcription factors translates to cellular mechanisms for division and differentiation and identify common and distinct regulatory networks in different stem cell populations.

干细胞对植物的生长和发育至关重要，是所有农业和林业的最终来源。虽然干细胞的建立和维持所需的一些关键基因被确定，但我们缺乏关于不同干细胞群体的细胞分化和细胞周期网络的信息，这些机制如何决定不同干细胞群体的共同和特定行为，以及它们如何将干细胞活性与不断变化的环境条件相结合。该提案整合了世界领先的实验室的工作，这些实验室对茎、根和维管分生组织的干细胞群、细胞周期控制、生长建模和图像分析进行了关键研究。欧洲在植物干细胞研究和细胞分裂控制方面处于全球领先地位，该提案将整合不同实验室的研究，创造新的协同效应和实质性的附加值。结合基因组学、反向遗传学、智能遗传筛选和新型细胞生物学的新工具和策略将被利用来解决转录因子如何将干细胞区域的规范转化为分裂和分化的细胞机制的关键问题，并确定不同干细胞群体中共同和独特的调控网络。