Analysis of the role of anti-citrullinated peptide antibody in RA pathogenesis to aim developing optimal treatment.

分析抗瓜氨酸肽抗体在 RA 发病机制中的作用，旨在制定最佳治疗方法。

• 批准号: 18K08411
• 负责人: IWAMOTO Naoki
• 金额: $ 2.75万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2018
• 资助国家: 日本
• 起止时间: 2018-04-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18K08411/
• 关键词: 関節リウマチ; 抗CCP抗体; 破骨細胞; アバタセプト; ケモカイン; 単球; M1単球; 滑膜線維芽細胞; 骨芽細胞; 滑膜細胞; M1・M2単球

项目成果

HR-pQCTによる関節リウマチ治療経過における骨微細構造変化の解析

HR-pQCT分析类风湿性关节炎治疗过程中骨微结构变化

• 发表时间: 2019
• 作者: Endo Yushiro;Koga Tomohiro;Suzuki Takahisa;Hara Kazusato;Ishida Midori;Fujita Yuya;Tsuji Sosuke;Takatani Ayuko;Shimizu Toshimasa;Sumiyoshi Remi;Igawa Takashi;Umeda Masataka;Fukui Shoichi;Nishino Ayako;Kawashiri Shin-ya;Iwamoto Naoki et al.;岩本直樹;岩本直樹;岩本直樹;岩本直樹;岩本直樹;岩本直樹
• 通讯作者: 岩本直樹

Denosumab is effective toward glucocorticoid-induced osteoporosis patients complicated with rheumatic diseases regardless of prior anti-osteoporotic drugs

• DOI: 10.1007/s00774-018-0955-7
• 发表时间: 2019-05-01
• 期刊: JOURNAL OF BONE AND MINERAL METABOLISM
• 影响因子: 3.3
• 作者: Iwamoto, Naoki;Okamoto, Momoko;Kawakami, Atsushi
• 通讯作者: Kawakami, Atsushi

Rheumatoid arthritis patients with low baseline Health Assessment Questionnaire scores have a risk of functional disability progression: a post hoc analysis of a nationwide longitudinal cohort in Japan.

基线健康评估问卷得分较低的类风湿性关节炎患者有功能障碍进展的风险：对日本全国纵向队列的事后分析。

• 发表时间: 2020
• 期刊: Clin Exp Rheumatol.
• 作者: Sumiyoshi R;Hidaka T;Koga T;Okada A;Fukuda T;Ishii T;Ueki Y;Kodera T;Nakashima M;Takahashi Y;Honda S;Horai Y;Watanabe R;Okuno H;Aramaki T;Izumiyama T;Takai O;Miyashita T;Kawashiri SY;Iwamoto N,
• 通讯作者: Iwamoto N,

Gastric Perforation due to Iatrogenic Immunodeficiency-associated Lymphoproliferative Disorder during the Treatment of Rheumatoid Arthritis

类风湿性关节炎治疗期间医源性免疫缺陷相关淋巴增殖性疾病导致胃穿孔

• DOI: 10.2169/internalmedicine.2782-19
• 发表时间: 2019
• 期刊: Internal Medicine
• 影响因子: 1.2
• 作者: Toyama Shiho;Takatani Ayuko;Iwamoo Naoki;Kawakami Atsushi et al.
• 通讯作者: Kawakami Atsushi et al.

The efficacy of denosumab in glucocorticoid-induced osteoporosis did not depend on prior treatment but was affected by the dosage of glucocorticoid

狄诺塞麦治疗糖皮质激素引起的骨质疏松症的疗效不依赖于既往治疗，而是受糖皮质激素剂量的影响

• 发表时间: 2018
• 作者: Endo Yushiro;Koga Tomohiro;Suzuki Takahisa;Hara Kazusato;Ishida Midori;Fujita Yuya;Tsuji Sosuke;Takatani Ayuko;Shimizu Toshimasa;Sumiyoshi Remi;Igawa Takashi;Umeda Masataka;Fukui Shoichi;Nishino Ayako;Kawashiri Shin-ya;Iwamoto Naoki et al.;岩本直樹;岩本直樹;岩本直樹;岩本直樹;岩本直樹;岩本直樹;岩本直樹;岩本直樹
• 通讯作者: 岩本直樹