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Identification of microRNA which play important role in Sjogren's Syndrome

Identification of microRNA which play important role in Sjogren's Syndrome
鉴定在干燥综合征中起重要作用的 microRNA
批准号:
24890165
负责人:
IWAMOTO Naoki
金额:
$1.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Research Activity Start-up
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-08-31 至 2014-03-31

项目摘要

项目成果

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中文摘要
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英文摘要
We found miR-181b was up-regulated in Sjogren syndrome (SS) salivary epithelial cells as compared with controls. The stimulation of IFN-gmma decreased the levels of miR-181b. Our data suggested that in SS, miR-181b was up-regulated and IFN-gamma regulates the expression of miR-181b in SS salivary gland. Thereby upregulation of miR-181b might play important role in pathogenesis of SS. Future experiment about function of miR-181b in SS and analysing predicted target of miR-181b are needed.
期刊论文(27)
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会议论文
An elderly patient with chronic active Epstein–Barr virus infection with mixed cryoglobulinemia and review of the literature
1例慢性活动性EB病毒感染合并混合性冷球蛋白血症的老年患者并文献复习
DOI: 10.3109/s10165-012-0731-9
发表时间: 2013
期刊: Modern Rheumatology
影响因子: 2.2
作者: [K. Ichinose, T. Origuchi, N. Tashiro, S. Kawashiri, N. Iwamoto, K. Fujikawa, T. Aramaki, K. Arima, M. Tamai, S. Yamasaki, Hideki Nakamura, H. Moriuchi, A. Kawakami]
通讯作者: A. Kawakami
分類不能関節炎に対するアバタセプトの効果
阿巴西普对无法分类的关节炎的影响
DOI: --
发表时间: 2012
期刊: リウマチ科
影响因子: --
作者: [須田 健一,  他, 岩本直樹]
通讯作者: 岩本直樹
Magnetic resonance imaging (MRI) detection of synovitis and bone lesions of the wrists and finger joints in early-stage rheumatoid arthritis : comparison of the accuracy of plain MRI-based findings and gadolinium-diethylenetriamine pentaacetic acid-enhanc
磁共振成像(MRI)检测早期类风湿性关节炎手腕和手指关节的滑膜炎和骨病变:基于平扫MRI的结果与钆二乙烯三胺五乙酸增强的准确性比较
DOI: --
发表时间: 2012
期刊: Mod Rheumatol
影响因子: 2.2
作者: [Tamai M, Iwamoto N]
通讯作者: Iwamoto N
Downregulation of miR-193b in systemic sclerosis contributes to the proliferative vasculopathy via uPA-uPAR independent pathway.
系统性硬化症中 miR-193b 的下调通过 uPA-uPAR 独立途径导致增殖性血管病变。
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [Iwamoto N, Distler O, 岩本直樹, 岩本直樹]
通讯作者: 岩本直樹
22
    Analysis of the role of anti-citrullinated peptide antibody in RA pathogenesis to aim developing optimal treatment.
    • 批准号:
      18K08411
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.75万
    • 财政年份:
      2018
    • 负责人:
      IWAMOTO Naoki
    • 依托单位:
    Modulation of cell function by microRNA in rheumatoid arthritis.
    • 批准号:
      16K19605
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.5万
    • 财政年份:
      2016
    • 负责人:
      IWAMOTO Naoki
    • 依托单位:
    MicroRNA modulate the function of fibroblast-like cells inRheumatoid Arthritis
    • 批准号:
      26860753
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.41万
    • 财政年份:
      2014
    • 负责人:
      IWAMOTO Naoki
    • 依托单位:
    A Scientific Study of the Tale of the Heike-A Quantitative Study of "the Fan Target"
    • 批准号:
      23650514
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $1.5万
    • 财政年份:
      2011
    • 负责人:
      IWAMOTO Naoki
    • 依托单位:
    海外基金