Rolle der alimentären und genetischen Modulation des Fettsäurestatus für das Erkrankungsrisiko für Typ 2 Diabetes mellitus

饮食和脂肪酸状态基因调节对 2 型糖尿病风险的作用

• 批准号: 36208128
• 负责人: Professor Dr. Matthias Bernd Schulze
• 金额: --
• 依托单位: Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke (DIfE)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2007
• 资助国家: 德国
• 起止时间: 2006-12-31 至 2011-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/36208128?language=en
• 关键词: Rolle; der; aliment; ren; und

Fatty acid biomarkers provide an integrated measure of dietary exposure and allow detecting alterations in fatty acid metabolism. Fatty acid profiles of erythrocyte membranes were related to risk of type 2 diabetes and plasma levels of CRP and adiponectin in the EPIC-Potsdam study. These findings and analyses on genetic variants in FADS1-FADS2 highlight a potential role of desaturases involved in fatty acid metabolism in the pathogenesis of diabetes. We aim to elucidate potential pathways underlying the association between fatty acid profiles and diabetes risk by evaluating prediabetic markers as well as metabolomic profiles using effect decomposition methodology and path analysis. In addition, we will identify food patterns related to fatty acid profiles and determine whether these patterns are related to diabetes risk. We furthermore aim to evaluate whether fatty acid markers are informative extensions to the German Diabetes Risk Score, a diabetes prediction model developed in EPIC-Potsdam.

脂肪酸生物标志物提供了膳食暴露的综合测量，并允许检测脂肪酸代谢的变化。epic -波茨坦研究中，红细胞膜脂肪酸谱与2型糖尿病风险、血浆CRP和脂联素水平相关。这些发现和对FADS1-FADS2基因变异的分析强调了参与脂肪酸代谢的去饱和酶在糖尿病发病机制中的潜在作用。我们的目标是通过使用效应分解方法和路径分析评估糖尿病前期标志物以及代谢组学特征，阐明脂肪酸谱与糖尿病风险之间关联的潜在途径。此外，我们将确定与脂肪酸谱相关的食物模式，并确定这些模式是否与糖尿病风险有关。我们进一步的目的是评估脂肪酸标志物是否是德国糖尿病风险评分的信息延伸，这是epic -波茨坦开发的糖尿病预测模型。

项目成果

Associated factors of estimated desaturase activity in the EPIC-Potsdam study.

• DOI: 10.1016/j.numecd.2013.10.029
• 发表时间: 2014-05
• 期刊: Nutrition, metabolism, and cardiovascular diseases : NMCD
• 作者: K. Schiller;S. Jacobs;E. Jansen;C. Weikert;R. Giuseppe;Heiner Boeing;Matthias B. Schulze;J. Kröger

Omega-3 and Omega-6 Fatty Acids and Type 2 Diabetes

• DOI: 10.1007/s11892-012-0362-8
• 发表时间: 2013-04-01
• 期刊: CURRENT DIABETES REPORTS
• 影响因子: 4.2
• 作者: Jeppesen, Charlotte;Schiller, Katja;Schulze, Matthias B.
• 通讯作者: Schulze, Matthias B.