Novel superparamagnetic, luminescent nanoparticles for magnetic particle imaging (MPI) applications (SuLuMaP)

用于磁粒子成像 (MPI) 应用的新型超顺磁性发光纳米粒子 (SuLuMaP)

• 批准号: 363034336
• 负责人: Professorin Dr. Esther Rösch
• 金额: --
• 依托单位: Studiengang Sustainable Science and Technology
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/363034336?language=en
• 关键词: Novel; superparamagnetic; luminescent; nanoparticles; magnetic

The aim of the research concept is to provide new bifunctional MPI tracer that combine superparamagnetic and luminescent properties, taking into account the most important factors such as quantum efficiency, biocompatibility, cell permeability, superparamagnetic and hydrodynamic radius, in order to increase the significance of multimodal diagnoses. The bifunctionality allows a complementary imaging approach. These tracers can be used for optical imaging to measure near-surface tracer distributions as two-dimensional projections with great spatial resolution at relatively low instrumental expense. Its use in MPI with substantially higher instrumental expense provides three-dimensional images of the tracer distribution in low-lying areas of the object of interest. Multimodal hybrid systems such as the recently introduced 3D dual-modal MPI-MRI system will be increasingly used in future. Recent research activities are concerned with cell tracking and describe the application of SPIO (superparamagnetic iron oxide nanoparticles) or 19F nanoemulsions, to perform multi-modal imaging using X-ray and MRI. In addition to luminescent lanthanide, also biocompatible organic dyes are going to be used. The hydrodynamic radius, which is responsible for the slowing of the relaxation, should be adjusted by means of the hydrophilic / hydrophobic surface property. For this purpose fluorinated compounds are being considered. There are four possibilities for the fluorination of the particles: 1) use of fluorinated polymers as coating for the magnetite 2) coupling of fluorinated organic dyes 3) use of fluorinated linkers with which the cell permeability can be enabled 4) end capping the free carboxyl - or silanol groups on the surface with fluorinated alkanes or dendrons. Due to these various options of fluorination of the particles, a fine adjustment of the surface polarity is possible which will be elaborated in systematic trials.

该研究概念的目的是提供一种结合超顺磁和发光特性的新型双功能MPI示踪剂，同时考虑量子效率、生物相容性、细胞渗透性、超顺磁和流体动力半径等最重要的因素，以提高多模态诊断的意义。双功能允许互补成像方法。这些示踪剂可用于光学成像，以二维投影的形式测量近地表示踪剂分布，具有很高的空间分辨率，仪器费用相对较低。它在MPI中使用，仪器费用高得多，可提供感兴趣对象低洼地区示踪剂分布的三维图像。多模态混合系统，如最近推出的3D双模态MPI-MRI系统，将在未来得到越来越多的应用。最近的研究活动涉及细胞跟踪和描述SPIO（超顺磁性氧化铁纳米颗粒）或19F纳米乳液的应用，使用x射线和MRI进行多模态成像。除了发光的镧系元素外，还将使用生物相容性有机染料。水动力半径是减缓弛豫的原因，应该通过亲疏水的表面性质来调节。为此目的，正在考虑含氟化合物。颗粒氟化有四种可能性：1)使用氟化聚合物作为磁铁矿的涂层；2)氟化有机染料的偶联；3)使用可以使细胞通透性的氟化连接剂；4)用氟化烷烃或树突覆盖表面上的游离羧基或硅醇基。由于颗粒氟化的这些不同选择，表面极性的细微调整是可能的，这将在系统试验中详细说明。