Nanoarchitectured multifunctional porous superparamagnetic nanoparticles

纳米结构多功能多孔超顺磁性纳米粒子

• 批准号: DP190102944
• 负责人: Prof Yusuke Yamauchi
• 金额: $ 12.64万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-06-27 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190102944
• 关键词: Nanoarchitectured; multifunctional; porous; superparamagnetic; nanoparticles

This project aims to develop a method for the direct detection of biomarkers based on a new class of highly porous superparamagnetic nanoparticles with peroxidase-like activity. The particles will be used as dispersible capture agents for isolating specific targets in biological samples, and electrocatalytic nanozymes for naked-eye evaluation and electrochemical detection. The project is expected to develop simple, low-cost, portable devices for the analysis of exosomes and exosomal miRNA in biological samples. The future development of this technology into diagnostic devices will improve patient outcomes by enabling earlier disease diagnosis and improved monitoring of treatment.

本项目旨在开发一种直接检测生物标志物的方法，该方法基于一类具有类似过氧化物酶活性的新型高孔超顺磁性纳米颗粒。这些颗粒将被用作分散捕捉剂，用于分离生物样品中的特定目标，以及电催化纳米酶，用于肉眼评估和电化学检测。该项目预计将开发简单、低成本、便携的设备，用于分析生物样本中的外体和外体miRNA。这项技术未来发展成为诊断设备，将通过实现更早的疾病诊断和改善对治疗的监测来改善患者的预后。