From Pavlov to Pain: Extinction Learning in Visceral pain (A10)

来自肠道的内感受信号，特别是内脏疼痛，可能会以某种方式塑造学习和记忆过程，尽管它们具有深刻的临床意义，但仍然没有完全理解。实施条件反射范式，涉及伤害性内脏和非伤害性听觉威胁，我们将进行双盲，随机，安慰剂对照的行为研究，以测试特定模式的压力激素皮质醇对消退功效的影响。在一个新的上下文依赖的内感受性条件反射范式与内感受性CS，我们将进一步描绘的神经基础的上下文内感受性威胁和安全学习，灭绝，和恐惧的复苏作为假定的机制参与内感受性过度警觉的肠-脑轴的疾病。

Interoceptive signals arising from the gut, especially visceral pain, may shape learning and memory processes in ways that, despite their profound clinical relevance, remain incompletely understood. Implementing a conditioning paradigm involving nociceptive visceral and non-nociceptive auditory threats, we will conduct a double-blind, randomized, placebo-controlled behavioral study to test modality-specific effects of the stress hormone cortisol on extinction efficacy. In a novel context-dependent interoceptive conditioning paradigm with interoceptive CS, we will further delineate neural underpinnings of contextual interoceptive threat and safety learning, extinction, and the resurgence of fear as putative mechanisms involved in interoceptive hypervigilance in disorders of the gut-brain axis.