Study of skin innate immune response in cutaneous adverse effects caused by molecular targeted agents

分子靶向药物引起的皮肤不良反应中皮肤先天免疫反应的研究

• 批准号: 18K16037
• 负责人: OMMORI RIE
• 金额: $ 2.66万
• 依托单位: Nara Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2018
• 资助国家: 日本
• 起止时间: 2018-04-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18K16037/
• 关键词: EGFR阻害薬; 分子標的治療薬; 薬疹; ざ瘡様皮疹; 自然免疫応答; 抗菌ペプチド; human β-defensin

项目成果

Human β-defensins are involved with pathological mechanism of cutaneous adverse effects caused by EGFR inhibitors.

人β-防御素参与EGFR抑制剂引起的皮肤不良反应的病理机制。

• 发表时间: 2019
• 作者: Rie Ommori;Fumi Miyagawa;Hiroaki Azukizawa;Hideo Asada
• 通讯作者: Hideo Asada

Reduced induction of human β-defensins is involved in the pathological mechanism of cutaneous adverse effects caused by EGFR monoclonal antibodies

人β-防御素诱导减少参与EGFR单克隆抗体引起皮肤不良反应的病理机制

• 发表时间: 2020
• 作者: Rie Ommori;Yuki Nakamura;Fumi Miyagawa;Chinatsu Shobatake;Kohei Ogawa;Fumikazu Koyama;Masayuki Sho;Ichiro Ota;Tadashi Kitahara;Shigeto Hontsu;Sigeo Muro;Hideo Asada.
• 通讯作者: Hideo Asada.

Reduced induction of human β-defensins is involved in the pathological mechanism of cutaneous adverse effects caused by epidermal growth factor receptor monoclonal antibodies.

人β-防御素诱导减少参与表皮生长因子受体单克隆抗体引起皮肤不良反应的病理机制。

• DOI: 10.1111/ced.14311
• 发表时间: 2020
• 期刊: Clin Exp Dermatol
• 影响因子: 4.1
• 作者: Ommori R;Nakamura Y;Miyagawa F;Shobatake C;Ogawa K;Koyama F;Sho M;Ota I;Kitahara T;Hontsu S;Muro S;Asada H
• 通讯作者: Asada H

Serum thymus and activation-regulated chemokine is associated with the severity of drug reaction with eosinophilia and systemic symptoms/drug-induced hypersensitivity syndrome.

血清胸腺和活化调节趋化因子与嗜酸性粒细胞增多和全身症状/药物诱发的过敏综合征的药物反应的严重程度相关。

• DOI: 10.1111/bjd.16132
• 发表时间: 2018
• 期刊: Br J Dermatol
• 作者: Nakamura-Nishimura Y;Miyagawa F;Miyashita K;Ommori R;Azukizawa H;Asada H
• 通讯作者: Asada H

EGFR阻害薬による皮膚障害の発症機序

EGFR抑制剂引起的皮肤病的发病机制

• 发表时间: 2018
• 作者: Arimura Akiko;Fujii Kazuyasu;Uchida Youhei;Higashi Yuko;Arima Naosuke;Yoshimitsu Makoto;Ishitsuka Kenji;Kanekura Takuro;御守里絵
• 通讯作者: 御守里絵