Extended fetal monitoring by systematic analysis of fetal autonomic cardiovascular regulation

通过系统分析胎儿自主心血管调节来扩展胎儿监测

• 批准号: 375203892
• 负责人: Professor Dr.-Ing. Hagen Malberg
• 金额: --
• 依托单位: Institut für Biomedizinische Technik (IBMT)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/375203892?language=en
• 关键词: Extended; fetal; monitoring; systematic; analysis

The clinically available procedures for assessing the fetal health and development status are still too imprecise today and are only partially suitable for prognostic applications. In the early gestational age, they are sometimes not applicable at all. The aim of the project is to characterize the fetal condition during the early gestational age (20 - 28 weeks of pregnancy) by the analysis of fetal cardiovascular regulation. To this end, the innovative system-analytic approach is used to characterize the dynamics of fetal heart rate variability as a function of internal and external factors of influence, that is, to conduct a context-based fetal variability analysis. The information obtained from this is to be used in the future for preventive treatment, not least for the determination of the optimal time of onset of complications. In the context of a clinical study, the project will demonstrate for the first time, using biomedical methods of the context-based variability analysis, that (1) a characteristic longitudinal development of the fetal autonomous regulation can be shown and (2) the monitoring of this development is the basis for an improved supply of risk pregnancies, which can decisively influence the decision on interventions in the early gestational age.

目前临床上用于评估胎儿健康和发育状态的程序仍然不够精确，并且仅部分适合预后应用。在孕早期，它们有时根本不适用。该项目的目的是通过分析胎儿心血管调节来表征孕早期（怀孕 20 - 28 周）的胎儿状况。为此，采用创新的系统分析方法将胎心率变异性的动态特征描述为内部和外部影响因素的函数，即进行基于上下文的胎儿变异性分析。由此获得的信息将在未来用于预防性治疗，尤其是确定并发症发生的最佳时间。在临床研究的背景下，该项目将首次证明，利用基于背景的变异性分析的生物医学方法，（1）可以显示胎儿自主调节的特征性纵向发展，（2）对这种发展的监测是改善风险妊娠供应的基础，这可以对孕早期干预决策产生决定性影响。