Continuous fractionation of fine particles using magnetically controlled countercurrent chromatographyPart II: Extension of the processable material classes as well as scaling and optimization of the multidimensional separation process.

在SPP2045的框架内，当前和提议的项目的首要目标是为磁性和非磁性纳米颗粒悬浮液开发一种新的多维分选工艺。该工艺应可扩展到工业规模，并能够连续运行。该技术开发的起点是正在申请专利的想法，将连续逆流色谱的优点与纳米颗粒上的叠加磁力相结合。这就产生了几种可探索的方法来实现所需的多维性。一方面，粒子所受的磁力除了与明显的材料和尺寸相关外，还是粒子形状的函数。另一方面，最终的分离还受到其他变量的影响，例如悬浮颗粒的流体的磁性和水动力阻力。在第一个资助期成功地进行概念验证后，拟议的后续项目的目标是扩大和优化处理工业相关颗粒数量的过程的潜力，并扩大应用领域，以对准磁性和反磁性纳米颗粒进行多维分选。

The overriding objective of both, the current as well as the proposed project within the framework of SPP2045 is the development of a novel multidimensional fractionation process for magnetic and non-magnetic nanoparticle suspensions. The process should be scalable to industrial scale and enable continuous operation. The starting point for the technology development is the patent pending idea of combining the advantages of continuous countercurrent chromatography with a superimposed magnetic force onto the nanoparticles. This results in several explorable approaches for achieving the required multidimensionality. On the one hand, the magnetic force on a particle is a function of the particle shape in addition to the obvious material and size dependence. On the other hand, the final separation is also influenced by other variables, such as the magnetic properties of the fluid in which the particles are suspended and the hydrodynamic resistance.After the successful proof-of-concept in the first funding period, the objectives of the proposed follow-up project are to scale and optimize the process with regard to its potential for processing industrially relevant particle quantities and to broaden the field of application towards a multidimensional fractionation of para- and diamagnetic nanoparticles.