Continuous fractionation of fine particles using magnetically controlled countercurrent chromatographyPart II: Extension of the processable material classes as well as scaling and optimization of the multidimensional separation process.

在SPP 2045的框架内，当前和拟议项目的首要目标是开发一种用于磁性和非磁性纳米颗粒悬浮液的新型多维分级过程。该工艺应可扩展到工业规模，并能够连续操作。该技术开发的起点是正在申请专利的想法，即将连续逆流色谱的优点与叠加在纳米颗粒上的磁力相结合。这导致了几种可探索的方法来实现所需的多维性。一方面，颗粒上的磁力除了明显的材料和尺寸依赖性之外，还是颗粒形状的函数。另一方面，最终的分离还受到其他变量的影响，如悬浮颗粒的流体的磁性和流体动力学阻力等，在第一个资助期成功进行概念验证后建议的目标如下：该项目的目的是扩大和优化工艺，以提高其处理工业相关颗粒量的潜力，并扩大涉及帕拉磁性和反磁性纳米颗粒的多维分级的应用领域。

The overriding objective of both, the current as well as the proposed project within the framework of SPP2045 is the development of a novel multidimensional fractionation process for magnetic and non-magnetic nanoparticle suspensions. The process should be scalable to industrial scale and enable continuous operation. The starting point for the technology development is the patent pending idea of combining the advantages of continuous countercurrent chromatography with a superimposed magnetic force onto the nanoparticles. This results in several explorable approaches for achieving the required multidimensionality. On the one hand, the magnetic force on a particle is a function of the particle shape in addition to the obvious material and size dependence. On the other hand, the final separation is also influenced by other variables, such as the magnetic properties of the fluid in which the particles are suspended and the hydrodynamic resistance.After the successful proof-of-concept in the first funding period, the objectives of the proposed follow-up project are to scale and optimize the process with regard to its potential for processing industrially relevant particle quantities and to broaden the field of application towards a multidimensional fractionation of para- and diamagnetic nanoparticles.