Electrochemical fluidized bed reactors for electro-enzymatic syntheses including gaseous phases: Part II. Modelling, Scale-up and in-line process monitoring

用于电酶合成（包括气相）的电化学流化床反应器：建模、放大和在线过程监控。

• 批准号: 445807856
• 负责人: Professor Dr.-Ing. Matthias Franzreb
• 金额: --
• 依托单位: Institut für Funktionelle Grenzflächen (IFG)
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/445807856?language=en
• 关键词: Electrochemical; fluidized; bed; reactors; electro

The overall objective of the proposed project is the further development of three-phase fluidized bed electrochemical reactors as highly promising systems for electro-enzymatic – and in perspective – also electro-microbial synthesis of value-added products. The foci of the work packages in the second funding period are in particular: (i) the development of a design which allows to effectively scale the reactor into industrially relevant dimensions and to allow the comfortable handling and exchange of enzyme carriers to enable long-term operation, (ii) to implement a flexible and sensitive real-time analysis of the reactants of the synthesis by coupling the reactor to a mass spectrometer (MS). The fast adaption of MS to various target molecules will allow the investigation of different electro-enzymatic reaction systems, while the real-time character of the analysis will allow kinetically resolved insights into correlations between electrical and chemical performance indicators, (iii) to extend and generalize the modelling activities in order to gain a comprehensive knowledge about process limitations, especially in scaled reactors running at elevated current densities. The correlations learned, will be transferred into general design rules and flexible model apps will be implemented on a COMSOL server for general use without the need for a COMSOL license or detailed modelling knowledge.

拟议项目的总体目标是进一步开发三相流化床电化学反应器，作为电酶法（从长远来看）以及增值产品的电微生物合成的极具前景的系统。第二资助期工作包的重点特别是：（i）开发一种设计，允许有效地将反应器扩展至工业相关尺寸，并允许舒适地处理和交换酶载体以实现长期运行，（ii）通过将反应器与质谱仪（MS）耦合，对合成反应物进行灵活和灵敏的实时分析。 MS 对各种目标分子的快速适应将允许研究不同的电酶反应系统，而分析的实时特性将允许对电气和化学性能指标之间的相关性进行动力学解析的洞察，(iii) 扩展和概括建模活动，以获得有关过程限制的全面知识，特别是在以高电流密度运行的规模化反应器中。学到的相关性将被转化为通用设计规则，并且灵活的模型应用程序将在 COMSOL 服务器上实现以供一般使用，而无需 COMSOL 许可证或详细的建模知识。