Hetero-Sequenced Cage Compounds as Bio-Inspired Molecular Flasks

异序笼状化合物作为仿生分子烧瓶

• 批准号: 384747028
• 负责人: Dr. Matthias Otte
• 金额: --
• 依托单位: Institut für Anorganische Chemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/384747028?language=en
• 关键词: Hetero; Sequenced; Cage; Compounds; Bio

The efficient catalysis of chemical reactions is of substantial importance to modern society. For the development of new catalysts, The efficient catalysis of chemical reactions is of substantial importance to modern society. For the development of new catalysts, chemists are often inspired by nature.Natures catalysts are enzymes. Those can catalyze chemical reactions with great precision and efficiency. The reactions take at active sites place, which are in protected unsymmetrical pockets located. While the precise structure of most reactive sites is known, their exact way of how they operate is often not sufficiently understood.In this project the unsymmetrical pockets and active sites of enzymes will be through the use of synthetic compounds mimicked. Those mimics will be through the synthesis of new cage compounds obtained. The here synthesized cage compounds will offer unsymmetrical cavities that are similar to the unsymmetrical pockets of enzymes. Reactive sites that can catalyze chemical reactions will be in those synthetic cavities located. The cavities will be through the application of new synthetic concepts obtained. Through the use of these new synthetic and unsymmetrical cage compounds, it is aimed to mimic enzymes with an unprecedented precision. To mimic enzymes follows here two objectives.The first is the development of new catalysts, which should be able to choose their reaction partner based on their size. The selection occurs through the cage compound. This offers pores of a defined size, preventing undesired reaction partner to reach the cage interior where the active center is located. This concept of size-selective catalysis should be applied to the oxidation of organic compounds. Catalysts that are based on iron, manganese and copper will be used for the oxidation reactions. Size-selective catalysis can be of potential interest for the synthesis of pharmaceuticals or fine chemicals. In addition, it is important for the conversion of crude oil or biomass.The second goal is to obtain a better understanding on how active sites of important enzymes operate. To achieve this, models of these sites will be in the cage compounds reassembled. The cages will protect the sites and allow an easier investigation of those. Two very important motifs will be in particular studied. The first is an iron-complex, which is in enzymes that can catalyze many important oxidation reactions (among others the synthesis of penicillin). The second is the so-called iron-molybdenum-cofactor, which can transform nitrogen into ammonia. Ammonia is for the production of food of very high importance. Knowledge gained during this project may lead to the development of more efficient catalysts for ammonia synthesis.

化学反应的有效催化对现代社会具有重要意义。为了开发新的催化剂，化学反应的有效催化对现代社会具有重要意义。为了开发新的催化剂，化学家们经常从自然界中得到灵感。它们可以非常精确和高效地催化化学反应。反应发生在活性位点处，这些活性位点位于受保护的不对称口袋中。虽然大多数反应位点的精确结构是已知的，但它们如何运作的确切方式往往没有得到充分的理解。在这个项目中，酶的不对称口袋和活性位点将通过使用合成化合物来模拟。那些模拟物将通过合成新的笼状化合物而获得。这里合成的笼状化合物将提供类似于酶的不对称口袋的不对称空腔。可以催化化学反应的反应位点将位于那些合成空腔中。这些空腔将通过应用新的合成概念而获得。通过使用这些新的合成和不对称的笼状化合物，它旨在以前所未有的精度模拟酶。模拟酶有两个目标：第一是开发新的催化剂，这种催化剂应该能够根据其大小来选择它们的反应伙伴。通过笼化合物进行选择。这提供了限定尺寸的孔，防止不期望的反应伙伴到达活性中心所在的笼内部。这种尺寸选择性催化的概念应该应用于有机化合物的氧化。基于铁、锰和铜的催化剂将用于氧化反应。尺寸选择性催化在药物或精细化学品的合成中具有潜在的意义。此外，它对原油或生物质的转化也很重要。第二个目标是更好地了解重要酶的活性位点是如何运作的。为了实现这一点，模型将在这些网站的笼化合物重新组装。笼子将保护这些地点，并允许更容易地调查这些地点。将特别研究两个非常重要的主题。第一种是铁络合物，它存在于酶中，可以催化许多重要的氧化反应（其中包括青霉素的合成）。第二种是所谓的铁钼辅因子，它可以将氮转化为氨。氨对于生产食品具有非常重要的意义。在该项目期间获得的知识可能会导致开发更有效的氨合成催化剂。