Correction of hyperopia and presbyopia by biocompatible filler injection

通过生物相容性填充剂注射矫正远视和老花眼

• 批准号: 386697299
• 负责人: Dr. Christian Wertheimer
• 金额: --
• 依托单位: Wellmann Center for Photomedicine
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/386697299?language=en
• 关键词: Correction; hyperopia; presbyopia; biocompatible; filler

Subject area:Depending on the individual anatomical structure of the eye, there are different refractive errors that can restrict vision. Hyperopia affects 31.8% of the population. In addition the human lens loses its accommodative function with increasing age. Symptoms usual occur around the age of forty. The affected hyperopic patient is then presbyopic and can not see either near or far in the distance.Current state of surgical hyperopia and presbyopia correction:There are various surgical approaches to correct hyperopia. Unfortunately, these have considerable disadvantages in addition to the desired correction of the spherical equivalent of the hyperopia. The laser methods can only be used for low hyperopia and are accompanied by frequent regression, corrective surgical/laser procedures and disturbing light phenomena such as halos/glares and other higher order aberrations. The intraocular lenses lead to a loss of accommodation, the additive implantable lenses are available to only a few patients due to the narrow anterior chamber conditions in small hyperopic eyes. The current corneal implants are only approved for low refractive errors or for presbyopia therapy and also produce aberrations and thus a reduction in contrast sensitivity.Aim:The aim of this work is to achieve a stable hyperopia and presbyopia correction of higher refractive errors through biocompatible "corneal fillers".Methodology:A biocompatible transparent viscous filler is to be injected into one or more corneal pockets for corneal re-shaping. The pocket should be cut with the Femtolaser. The filler is then injected into the corneal pocket with a nano-injector. This is to be done by means of a precisely cut corneal tunnel, which seals itself by the corneal morphology and its shape (analougous to cataract clear corneal tunnels). The resulting steepening of the corneal front surface and / or flattening of its posterior surface cause an increase in the refractive power to be used for the correction of refraction in hyperopia and presbyopia. An oval cutted pocket can be used for the correction of astigmatism. By adding or removing filler material, the refraction can be fine-tuned as required.Important aspects of the project will be systematic studies on the biomechanical stability of the refraction correction and the biocompatibility of filler materials.

主题领域：根据眼睛的个体解剖结构，存在不同的屈光不正会限制视力。远视影响着 31.8% 的人口。此外，随着年龄的增长，人类的晶状体会失去调节功能。症状通常出现在四十岁左右。远视患者就会出现老花眼，无论看近还是看远都看不清。远视手术和老花眼矫正的现状：矫正远视的手术方法有多种。不幸的是，除了远视球镜的所需矫正之外，这些还有相当大的缺点。激光方法只能用于低度远视，并伴有频繁的回归、矫正手术/激光手术和干扰光现象，例如光晕/眩光和其他高阶像差。人工晶状体会导致调节能力丧失，由于小远视眼的前房条件狭窄，只有少数患者可以使用附加植入式晶状体。目前的角膜植入物仅被批准用于低屈光不正或老花眼治疗，并且还会产生像差，从而降低对比敏感度。目的：这项工作的目的是通过生物相容性“角膜填充物”实现稳定的远视和老花眼矫正较高的屈光不正。方法：将一种生物相容性透明粘性填充物注入一个或多个 用于角膜重塑的角膜袋。应使用 Femtolaser 切割口袋。然后用纳米注射器将填充剂注射到角膜袋中。这是通过精确切割的角膜隧道来完成的，角膜隧道通过角膜形态及其形状来密封自身（类似于白内障透明角膜隧道）。由此产生的角膜前表面变陡和/或其后表面变平导致用于矫正远视和老花眼屈光的屈光力增加。椭圆形切割袋可用于矫正散光。通过添加或去除填充材料，可以根据需要微调屈光度。该项目的重要方面将是对屈光矫正的生物力学稳定性和填充材料的生物相容性进行系统研究。