Peripheral optical and neural contributions to myopia development

周边光学和神经对近视发展的贡献

• 批准号: 10688125
• 负责人: GEUNYOUNG YOON
• 金额: $ 40.49万
• 依托单位: UNIVERSITY OF HOUSTON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10688125
• 关键词: Affect; Age of Onset; Anisotropy; Astigmatism; Blindness; Bypass; Characteristics; Child; Clinic; Coma; Contact Lenses; Contrast Sensitivity; Data; Development; Disease; Environment; Exposure to; Eye; Eye diseases; Genetic; Goals; Human; Hyperopia; Image; Individual; Intervention; Investigation; Life; Link; Long-Term Effects; Longitudinal Studies; Measurement; Measures; Methods; Myopia; Neurophysiology - biologic function; Optics; Peripheral; Play; Population; Prevalence; Process; Psychophysics; Radial; Refractive Errors; Retina; Risk Factors; Role; Scanning; Schools; Shapes; Space Perception; Testing; Thick; Time; Validation; Vision; Visual; Visual System; Visual impairment; adaptive optics; design; effective intervention; experimental study; improved; innovation; insight; lens; neural; novel; portability; prevent; response; retinal imaging; sample fixation; sensor; success; tool

Abstract Myopia (nearsightedness) is one of the foremost causes of visual impairment worldwide, with severe myopia being linked to several serious eye diseases that can result in permanent blindness. The prevalence of myopia has been increasing and is estimated to affect 50% of the world’s population by 2050. Despite the identification of many risk factors for myopia progression such as age of onset, genetics, visual environment, and peripheral defocus, causes of myopia are not fully understood. Current interventions have shown some success, but without a clear explanation for their mechanism of action. It is therefore critical to investigate the mechanisms underlying myopia development in order to design effective interventions to control the progression of myopia in children, and to delay or ultimately prevent onset altogether. Our long-term goal is to understand the influence of peripheral optical and neural factors on myopia development. The specific objective of this proposal is to test the central hypothesis that optical and neural anisotropy in the human peripheral visual system plays an important role in axial elongation. To achieve these goals we will develop and implement innovative optical tools including a compact scanning ocular wavefront sensor, an open-view scanning adaptive optics vision simulator, and individually-customized contact lenses. Aim 1 is directed at characterizing how different aberration profiles impact through-focus retinal image quality and neural functions. First, measuring lower and higher order ocular aberrations across retinal eccentricity will characterize individual retinal image quality and blur orientations. Neural anisotropy at the same eccentricities will then be evaluated by administering psychophysical tasks while bypassing the ocular optics using a scanning adaptive optics vision simulator. Aim 2 will focus on determining how intrinsic peripheral aberration profiles and eye shape change over time in school children. To do this, we will develop a compact portable scanning wavefront sensor that can be transported to and used in a clinic for measuring longitudinal changes of school children’s optics across retinal eccentricity. This will allow us to delineate relationships between changes in peripheral aberrations at the crucial stages of myopia development, in those children who develop myopia. Aim 3 is proposed to further investigate a role of blur orientations in detecting the sign of defocus and altering directional neural sensitivity in the peripheral retina. To achieve this goal, the retinal response in term of changes in choroidal layer thickness (short-term) and neural sensitivity (long-term) will be examined during and after the peripheral retina is exposed to specific blur orientations.

抽象的 近视（近视）是全世界视力损害的最主要原因之一，严重近视 与几种可能导致永久性失明的严重眼部疾病有关。近视患病率 一直在增加，预计到 2050 年将影响世界 50% 的人口。 近视发展的许多危险因素，如发病年龄、遗传、视觉环境和周围环境 散焦，近视的原因尚不完全清楚。目前的干预措施已取得一些成功，但 没有明确解释其作用机制。因此，研究其机制至关重要 找出近视发展的根本原因，以设计有效的干预措施来控制近视的发展 在儿童中，并延迟或最终完全预防发病。我们的长期目标是了解 周围光学和神经因素对近视发展的影响。此次活动的具体目标 提议是检验人类周边视觉中光学和神经各向异性的中心假设 系统在轴向伸长中起着重要作用。为了实现这些目标，我们将制定并实施 创新的光学工具，包括紧凑型扫描目镜波前传感器、开放式扫描 自适应光学视觉模拟器和单独定制的隐形眼镜。目标 1 旨在表征 不同的像差轮廓如何影响离焦视网膜图像质量和神经功能。第一的， 测量视网膜偏心率的低阶和高阶眼像差将表征个体 视网膜图像质量和模糊方向。然后将评估相同偏心率下的神经各向异性 通过使用扫描自适应光学器件绕过眼部光学器件来执行心理物理任务 视觉模拟器。目标 2 将重点确定固有周边像差分布和眼睛形状 在学儿童中随着时间的推移而发生变化。为此，我们将开发一种紧凑型便携式扫描波前传感器 可以运输到诊所并在诊所中使用，用于测量学童光学的纵向变化 跨越视网膜偏心率。这将使我们能够描绘外围变化之间的关系 近视发展关键阶段的像差。目标 3 是 建议进一步研究模糊方向在检测散焦和改变的迹象中的作用 周边视网膜的定向神经敏感性。为了实现这一目标，视网膜反应 将在期间和期间检查脉络膜层厚度（短期）和神经敏感性（长期）的变化 当周边视网膜暴露于特定的模糊方向后。

项目成果

Peripheral Choroidal Response to Localized Defocus Blur: Influence of Native Peripheral Aberrations.

周边脉络膜对局部散焦模糊的反应：原生周边像差的影响。

• DOI: 10.1167/iovs.65.4.14
• 发表时间: 2024
• 期刊: Investigative ophthalmology & visual science
• 影响因子: 4.4
• 作者: Pusti,Dibyendu;Patel,NimeshB;Ostrin,LisaA;Nti,AugustineN;Das,Siddarth;Yoon,Geunyoung
• 通讯作者: Yoon,Geunyoung

Widefield wavefront sensor for multidirectional peripheral retinal scanning.

用于多方向周边视网膜扫描的宽场波前传感器。

• DOI: 10.1364/boe.491412
• 发表时间: 2023
• 期刊: Biomedical optics express
• 影响因子: 3.4
• 作者: Pusti,Dibyendu;DegreKendrick,Chloe;Wu,Yifei;Ji,Qiuzhi;Jung,HaeWon;Yoon,Geunyoung
• 通讯作者: Yoon,Geunyoung