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Exploring the efficacy of novel photobactericidals against planktonic and biofilm growing uropathogenic bacteria

探索新型光杀菌剂对浮游和生物膜生长的尿路致病菌的功效

基本信息

批准号：
388056781
负责人：
Professorin Dr. Anzhela Galstyan
金额：
--
依托单位：
WISNA-Juniorprofessur für Nanomaterialien in aquatischen Systemen
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2018
资助国家：
德国
起止时间：
2017-12-31 至 2021-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/388056781?language=en
关键词：
Exploring efficacy novel photobactericidals against

项目摘要

Worldwide thousands of patients suffer from urinary tract infection (UTI). Current treatments of UTI are commonly based on high concentration of systemically applied antibiotics. A disadvantage in this treatment lies in the promoted development of (multi)resistances. Antimicrobial photodynamic therapy is alternative, non-antibiotic based treatment method that allows us to meet current challenges in a very effective way; it does not lead to the selection of resistant mutants and can destroy pathogens in a short time frame by the combined action of a photosensitizer and near infrared light. The selective and specific binding of photosensitizer to lipopolysaccharides as particularly attractive targets is envisaged, complementing our previous work on the search for PSs that might be considered good candidates for the photoinactivation of Gram-negative bacteria. We aim to modulate the chemical structure of photosensitizers so that they can be rapidly taken up by Gram-negative bacteria at low concentrations and kill microorganisms but not damage the host tissue. The proteomic analysis will be used to increase our insight into the sequential steps by which microorganisms are photoinactivated. The resistance of bacterial biofilms against antibiotic treatment is one of the major reasons why those who get UTI are highly susceptible to getting more in the future. In this project, we aim to disperse formed biofilms upon photodynamic action. In addition, we will use the photosensitizers for the development of innovative, self-regulated coatings to prevent and treat catheter-associated urinary tract infections. Photocytotoxic characteristics of photosensitizers and model surfaces against a range of clinically important Gram-negative bacteria will be determined.

全世界成千上万的患者患有尿路感染（UTI）。目前UTI的治疗通常基于高浓度的全身应用的抗生素。这种处理的缺点在于促进了（多）抗性的发展。抗微生物光动力疗法是一种替代的、非抗生素的治疗方法，使我们能够以非常有效的方式应对当前的挑战;它不会导致选择耐药突变体，并且可以通过光敏剂和近红外光的联合作用在短时间内摧毁病原体。设想光敏剂与脂多糖作为特别有吸引力的靶点的选择性和特异性结合，补充了我们以前在寻找PS上的工作，PS可能被认为是革兰氏阴性菌光灭活的良好候选者。我们的目标是调节光敏剂的化学结构，使它们可以在低浓度下迅速被革兰氏阴性菌吸收，杀死微生物，但不损害宿主组织。蛋白质组学分析将用于增加我们对微生物被光灭活的顺序步骤的了解。细菌生物膜对抗生素治疗的耐药性是那些UTI患者在未来极易患上更多UTI的主要原因之一。在这个项目中，我们的目标是分散光动力作用形成的生物膜。此外，我们将使用光敏剂开发创新的自我调节涂层，以预防和治疗导管相关的尿路感染。将确定光敏剂和模型表面对一系列临床上重要的革兰氏阴性菌的光细胞毒性特征。

项目成果

期刊论文数量（12）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Facile Fabrication of Silicon(IV)Phthalocyanine-Embedded Poly(vinyl alcohol)-Based Antibacterial and Antifouling Interfaces.

DOI：
10.1021/acsabm.0c00347
发表时间：
2020-05
期刊：
ACS applied bio materials
影响因子：
4.7
作者：
Konstantin Strokov;A. Schäfer;U. Dobrindt;A. Galstyan
通讯作者：
Konstantin Strokov;A. Schäfer;U. Dobrindt;A. Galstyan

Biodegradable supramolecular micelles via host-guest interaction of cyclodextrin-terminated polypeptides and adamantane-terminated polycaprolactones.

DOI：
10.1039/d1cc03372g
发表时间：
2021-09
期刊：
Chemical communications
影响因子：
4.9
作者：
Sharafudheen Pottanam Chali;Suna Azhdari;A. Galstyan;André H. Gröschel;B. Ravoo
通讯作者：
Sharafudheen Pottanam Chali;Suna Azhdari;A. Galstyan;André H. Gröschel;B. Ravoo

Chitosan‐Silicon Phthalocyanine Conjugate as Effective Photo‐Functional Hydrogel for Tracking and Killing of Bacteria