Multifunctional photoactive nanocarriers for degradation of bacterial biofilms

用于降解细菌生物膜的多功能光活性纳米载体

• 批准号: 531205207
• 负责人: Professorin Dr. Anzhela Galstyan
• 金额: --
• 依托单位: WISNA-Juniorprofessur für Nanomaterialien in aquatischen Systemen
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/531205207?language=en
• 关键词: Multifunctional; photoactive; nanocarriers; degradation; bacterial

Biofilms are a common form of growth and survival for many bacteria. They are structurally complex and dynamic systems that are difficult to treat. Antimicrobial photodynamic therapy (aPDT) holds great promise in this regard and offers a viable alternative in an era where antibiotics may no longer be long-term options. While most evaluations of aPDT effects on biofilms have been conducted with molecular photosensitizers, the potential of nanocarrier systems with high mobility and diffusion into biofilms has been less studied. Due to the versatile and generic mechanisms of action of singlet oxygen or other reactive oxygen species, targeted aPDT offers the option to lyse specific biofilm components. We will take advantage of the versatility of synthesis and functional modifications of amphiphilic polymers to obtain a library of nanodelivery systems where charge, size, type of photosensitizer, and targeting moiety vary, giving us the opportunity to find the most efficient pathway for aPDT for biofilm treatments. Within this project, the photophysical properties and photobiological effects of photoactive nanocarriers will be investigated. The research approach covers all the main aspects we consider critical for the successful development of antibacterial therapeutics merging competencies in synthetic chemistry, nanotechnology, photochemistry, and microbiology.

生物膜是许多细菌生长和存活的常见形式。它们是结构复杂和动态的系统，难以治疗。抗菌光动力疗法（aPDT）在这方面有很大的希望，并在抗生素可能不再是长期选择的时代提供了一个可行的替代方案。虽然大多数aPDT对生物膜的影响的评估已经用分子光敏剂进行，但具有高迁移率和扩散到生物膜中的纳米载体系统的潜力研究较少。由于单线态氧或其他活性氧的作用机制的多样性和通用性，靶向aPDT提供了裂解特定生物膜组分的选择。 我们将利用两亲性聚合物的合成和功能修饰的多功能性来获得纳米递送系统的库，其中电荷，大小，光敏剂类型和靶向部分各不相同，使我们有机会找到最有效的aPDT生物膜治疗途径。本计画将探讨光活性奈米载体之光物理性质及光生物效应。研究方法涵盖了我们认为对成功开发抗菌治疗剂至关重要的所有主要方面，包括合成化学，纳米技术，光化学和微生物学。