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New technologies for a clinical establishment of microbeam radiation therapy

微束放射治疗临床建立的新技术

基本信息

批准号：
389238549
负责人：
Dr. Stefan Bartzsch
金额：
--
依托单位：
Klinikum rechts der Isar der Technischen Universität München (MRI)
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2017
资助国家：
德国
起止时间：
2016-12-31 至 2020-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/389238549?language=en
关键词：
New technologies clinical establishment microbeam

项目摘要

MIcrobeam radiation therapy (MRT) is an innovative, but still preclinical approach in radiation oncology that exploits arrays of parallel, a few tens of µm wide and a few 100 µm separated beamlets. Various preclinical studies showed that these spatially fractionated radiation fields are far less toxic to healthy, tumour surrounding tissue than homogeneous radiation fields at equivalent tumour control probability. Therefore a significant benefit is expected for the radiation therapy treatment of brain tumours, but also lung tumours, where the sensitivity of the surrounding normal tissue limits the application of higher therapeutic doses. So far clinically relevant microbeams can only be generated at large third generation synchrotrons such as the European Synchrotron in Grenoble. For a clinical translation of MRT, but also for preclinical research, alternative strategies to produce microbeams are urgently required, which is the aim of this project proposal.The project consists of two parts. In the first part a special multislit collimator will be developed for a small animal irradiator to produce microbeams for preclinical in-vivo research. In the future the device will be used for radiobiological research at the technical university Munich. In the second part of the project a concept of a compact microbeam source, which was worked out by the applicant, will be further developed, such that a prototype may be built in a subsequent project. This planning study comprises various numerical simulations and the investigation of technical solutions for the various components of the radiation source. After this project the small animal microbeam source will be used for biological in-vitro and in-vivo research and the investigation of the mechanisms behind MRT, without the need to use expensive and scarce beam time at large synchrotron facilities. The experience gained when constructing the preclinical source will contribute to a future realisation of the clinical concept. Apart from microbeam radiation therapy, the concept of the compact clinical microbeam source may also be of great interest to phase contrast imaging.

微束放射治疗（MRT）是一种创新的，但仍处于临床前的放射肿瘤学方法，它利用平行阵列，几十微米宽和几个100微米分离的光束。各种临床前研究表明，在同等肿瘤控制概率下，这些空间分异辐射场对健康肿瘤周围组织的毒性远低于均匀辐射场。因此，预期放射治疗对脑肿瘤和肺肿瘤有显著的益处，因为肺肿瘤周围正常组织的敏感性限制了高治疗剂量的应用。到目前为止，临床相关的微光束只能在第三代同步加速器上产生，比如格勒诺布尔的欧洲同步加速器。对于MRT的临床翻译，以及临床前研究，迫切需要生产微束的替代策略，这是本项目提案的目的。该项目由两部分组成。在第一部分中，将开发一种特殊的多缝准直器，用于小型动物辐照器产生用于临床前体内研究的微光束。未来，该装置将用于慕尼黑工业大学的放射生物学研究。在该项目的第二部分，将进一步发展由申请人设计的紧凑型微光束源的概念，以便在随后的项目中制造原型。这项规划研究包括各种数值模拟和对辐射源各组成部分的技术解决方案的调查。该项目完成后，小动物微光束源将用于生物体外和体内研究以及MRT背后机制的调查，而无需在大型同步加速器设施中使用昂贵和稀缺的光束时间。在构建临床前源时获得的经验将有助于临床概念的未来实现。除了微束放射治疗，紧凑的临床微束源的概念也可能是非常感兴趣的相对比成像。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

OC-0471: Optimization of a compact x-ray source for clinical microbeam radiation therapy

OC-0471：用于临床微束放射治疗的紧凑型 X 射线源的优化

DOI：
10.1016/s0167-8140(21)00493-x
发表时间：
2020
期刊：
Radiotherapy and Oncology
影响因子：
5.7
作者：
Winter;Wilkens;Bartzsch
通讯作者：
Bartzsch

First demonstration of real-time in-situ dosimetry of X-ray microbeams using a large format CMOS sensor

首次演示使用大幅面 CMOS 传感器对 X 射线微束进行实时原位剂量测定

DOI：
10.1016/j.nima.2020.164395
发表时间：
2020
期刊：
Nuclear Instruments & Methods in Physics Research Section A-accelerators Spectrometers Detectors and Associated Equipment
影响因子：
1.4
作者：
Flynn S;Price T;Allport PP;Patallo;Thomas R;Subiel A;Bartzsch S;Treibel F;Ahmed M;Jacobs-Headspith J
通讯作者：
Jacobs-Headspith J

PD-0933 Microbeam radiotherapy planning for a clinical lung tumor case

PD-0933 临床肺部肿瘤病例的微束放射治疗计划