权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Effects of Oxytocin on Socio-Cognitive Processes: New Insights from Spatio-Temporal EEG Analyses

催产素对社会认知过程的影响：时空脑电图分析的新见解

基本信息

批准号：
389805696
负责人：
Dr. Bastian Schiller
金额：
--
依托单位：
Abteilung Biologische Psychologie, Klinische Psychologie und Psychotherapie
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2017
资助国家：
德国
起止时间：
2016-12-31 至 2020-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/389805696?language=en
关键词：
Effects Oxytocin Socio Cognitive Processes

项目摘要

The neuropeptide oxytocin is a key modulator of social behavior and social cognition in humans. Given the plethora of intranasal application studies enforcing its role in social interactions, we know little about the effects of oxytocin on specific neural processes. Relying on over a decade of oxytocin research in humans, we have distilled four distinct oxytocin hypotheses: the Anxiety Reduction Hypothesis, Social Motivation Hypothesis, Social Salience Hypothesis, and Interactionist Hypothesis. Neuroimaging methods enable us to empirically test these hypotheses. In the spatial domain, metabolic neuroimaging studies have generated important insights about oxytocin-induced changes in neural activity during social interactions. In contrast, in the temporal domain, it is still largely unknown how oxytocin administration affects the dynamics of socio-cognitive neural processes. Therefore, in the current project, we intend to focus on various spatio-temporal analyses of electrophysiological brain activity in order to study how oxytocin affects the temporal dynamics of human social cognition and behavior.The goals of this project are to explore the effects of oxytocin on the temporal dynamics of the socio-cognitive processes associated with trust decisions (Subproject 1) and on resting neural networks (Subproject 2). After having received placebo or oxytocin via intranasal administration, participants will interact in an innovative trust game in which interaction partners are represented by computer-generated face photos. We will maintain experimental control over two attributes of these faces (threat, attractiveness) to put the distinct oxytocin hypotheses to an empirical test. Utilizing an innovative spatio-temporal analysis of event-related potentials, we aim to identify and time the entire sequence of neural processes during trust decisions. This analytic approach alone will enable us to answer the following research questions: How does oxytocin affect the intensity of socio-cognitive processes (intensify versus dampen)? How does oxytocin affect the duration of socio-cognitive processes (accelerate versus prolong)? How does oxytocin affect the type of socio-cognitive processes (eliminate versus add)? Furthermore, utilizing a spatio-temporal analysis of resting electroencephalography, we will analyze how oxytocin affects the occurrence of the neural resting networks associated with specific functions. Regarding all these research questions, we will derive specific predictions from the distinct oxytocin hypotheses. We hope to shed light on the validity of these hypotheses with respect to the effects of oxytocin on neural processing in social-cognitive behavior by empirically testing these predictions. We are confident that this project`s results are of interest to a wide variety of researchers including those in the areas of emotion processing, social interaction and cognition, and psychoneuroendocrinology.

神经肽催产素是人类社会行为和社会认知的关键调节剂。鉴于大量鼻内应用研究强调其在社会互动中的作用，我们对催产素对特定神经过程的影响知之甚少。根据十多年来对人类催产素的研究，我们提炼出四种不同的催产素假说：焦虑减少假说、社会动机假说、社会突出假说和互动假说。神经成像方法使我们能够对这些假设进行实证检验。在空间领域，代谢神经成像研究对社交互动中催产素诱导的神经活动变化产生了重要的见解。相比之下，在时间域，它仍然很大程度上是未知的催产素管理如何影响社会认知神经过程的动态。因此，在当前的项目中，我们打算重点研究脑电生理活动的各种时空分析，以研究催产素如何影响人类社会认知和行为的时间动态。本项目的目标是探索催产素对与信任决策相关的社会认知过程的时间动态的影响（子项目1）和对静息神经网络的影响（子项目2）。在通过鼻内注射安慰剂或催产素后，参与者将在一个创新的信任游戏中互动，在这个游戏中，互动伙伴由电脑生成的面部照片代表。我们将对这些面孔的两个属性（威胁，吸引力）进行实验控制，以将不同的催产素假设进行实证测试。利用事件相关电位的创新时空分析，我们的目标是识别和确定信任决策过程中的整个神经过程序列。这种分析方法将使我们能够回答以下研究问题：催产素如何影响社会认知过程的强度（增强还是减弱）？催产素如何影响社会认知过程的持续时间（加速还是延长）？催产素如何影响社会认知过程的类型（消除还是增加）？此外，利用静息脑电图的时空分析，我们将分析催产素如何影响与特定功能相关的神经静息网络的发生。对于所有这些研究问题，我们将从不同的催产素假设中得出具体的预测。我们希望通过对这些预测的实证检验，阐明关于催产素对社会认知行为中神经处理的影响的这些假设的有效性。我们相信，这个项目的结果会引起广泛的研究人员的兴趣，包括情绪处理、社会互动和认知以及精神神经内分泌学领域的研究人员。