Development of Iridium-catalyzed, intramolecular, asymmetric allylic alkylation reactions and their application towards the total synthesis of Aquilarabietic Acid H
铱催化分子内不对称烯丙基烷基化反应的发展及其在水木香枞酸 H 全合成中的应用
基本信息
- 批准号:390789510
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:德国
- 项目类别:Research Fellowships
- 财政年份:2017
- 资助国家:德国
- 起止时间:2016-12-31 至 2018-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Synthetic organic chemistry continues to be of highest importance within drug discovery and development, as well as medicinal chemistry. This led to increased interest in catalytic, enantioselective synthesis in recent years, particularly regarding difficult to access, quaternary stereocenters. Based on previous initial studies the research project will initially focus on developing an Iridium-catalyzed, intramolecular, asymmetric allylic alkylation reaction of 1,3-dicarbonyls. This would allow easy access to various carbocycles with vicinal quaternary-tertiary stereocenters. This new methodology is then to be applied to the total synthesis of Aquilarabietic Acid H, a novel natural compound that showed anti-depressant properties in initial studies. Further, the asymmetric, intramolecular reaction is then to be extended to substrates with carbocycle-containing allyl moieties. This would give easy access to polycyclic motifs commonly found in steroids and related pharmaceutical drugs.
合成有机化学在药物发现和开发以及药物化学中仍然是最重要的。这导致近年来对催化、对映选择性合成的兴趣增加,特别是难以获得的四元立体中心。基于先前的初步研究,该研究项目将首先集中于开发一种铱催化的1,3-二羰基的分子内不对称烯丙基烷基化反应。这样就可以很容易地得到具有相邻的第四-叔立体中心的各种碳环。这种新方法随后将被应用于Aquilarabietic Acid H的全合成,这是一种新的天然化合物,在最初的研究中显示出抗抑郁的特性。此外,不对称的分子内反应随后被扩展到含有碳环烯丙基的底物。这将使我们更容易接触到类固醇和相关药物中常见的多环基序。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Dr. Sebastian Lackner其他文献
Dr. Sebastian Lackner的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
相似海外基金
Iridium Catalyzed Homopyridylic Allylation of 4-Alkylpyridines
铱催化 4-烷基吡啶的均吡啶烯丙基化
- 批准号:
566038-2021 - 财政年份:2021
- 资助金额:
-- - 项目类别:
Alexander Graham Bell Canada Graduate Scholarships - Master's
Iridium-Catalyzed, Intramolecular Cyclization of Allylic Alcohols for Quaternary Center Synthesis
铱催化烯丙醇分子内环化季中心合成
- 批准号:
2137996 - 财政年份:2021
- 资助金额:
-- - 项目类别:
Fellowship Award
Syntheses of donor-acceptor pi-conjugated enamines catalyzed by Iridium complexes
铱配合物催化供体-受体π共轭烯胺的合成
- 批准号:
17K17944 - 财政年份:2017
- 资助金额:
-- - 项目类别:
Grant-in-Aid for Young Scientists (B)
Iridium-catalyzed efficient organic synthesis
铱催化高效有机合成
- 批准号:
25410119 - 财政年份:2013
- 资助金额:
-- - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development of Environmentally Benign Synthetic Organic Reactions Catalyzed by Water-Soluble Iridium Complexes Using Aqueous Ammonia as a Nitrogen Source
以氨水为氮源的水溶性铱配合物催化环境友好合成有机反应的进展
- 批准号:
23550121 - 财政年份:2011
- 资助金额:
-- - 项目类别:
Grant-in-Aid for Scientific Research (C)
RUI: Alkane Dehydrogenation Catalyzed by CCC-Pincer Complexes of Iridium
RUI:铱 CCC-钳配合物催化烷烃脱氢
- 批准号:
1057792 - 财政年份:2011
- 资助金额:
-- - 项目类别:
Continuing Grant
Mechanistic studies of iridium-catalyzed asymmetric hydrogenations of imines, quinolones and enones. Rational design of new chiral catalysts
铱催化亚胺、喹诺酮和烯酮不对称氢化的机理研究。
- 批准号:
175525703 - 财政年份:2010
- 资助金额:
-- - 项目类别:
Research Grants
Development of Iridium-Catalyzed Highly Selective Organic Synthesis
铱催化高选择性有机合成研究进展
- 批准号:
21550107 - 财政年份:2009
- 资助金额:
-- - 项目类别:
Grant-in-Aid for Scientific Research (C)
Iridium-catalyzed highly selective reactions
铱催化的高选择性反应
- 批准号:
18550098 - 财政年份:2006
- 资助金额:
-- - 项目类别:
Grant-in-Aid for Scientific Research (C)
Studies on the Use of Cationic Iridium(III) Complexes in Lewis Acid-Catalyzed C-C Bond-Forming Reactions
阳离子铱(III)配合物在路易斯酸催化C-C键形成反应中的应用研究
- 批准号:
0556225 - 财政年份:2006
- 资助金额:
-- - 项目类别:
Continuing Grant