Basic research for chronotherapy focused on liver regeneration andliver steatosis by circadian clock
Basic research for chronotherapy focused on liver regeneration andliver steatosis by circadian clock
批准号:
23659398
负责人:
TERAI Shuji
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
Medaka with HFD showed high NASH activity score (NAS), suggesting that circadian rhythm change is related to NASH progression. The light system is closely related with chronic inflammation by light stimulation. Collaboration with Oklahoma university, we found that NASH medaka developed diabetic nephropathy. These data showedmedaka fish model is useful to analyze the mechanism of NASH and nephropathyand to develop a new chronotherapy.
期刊论文(9)
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DOI:
10.1016/j.bbrc.2011.09.067
发表时间:
2011-10-22
期刊:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子:
3.1
作者:
[Fujisawa, Koichi, Terai, Shuji, Sakaida, Isao]
通讯作者:
Sakaida, Isao
Medaka fish, Oryzias latipes, as a model for human obesity-related glomerulopathy.
Medaka Fish,Oryzias latipes,作为与肥胖相关的肾小球病的模型。
DOI:
10.1016/j.bbrc.2013.01.053
发表时间:
2013-02-22
期刊:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子:
3.1
作者:
[Ichimura, Koichiro, Kawashima, Yusuke, Nakamura, Tomomi, Powell, Rebecca, Hidoh, Yuya, Terai, Shuji, Sakaida, Isao, Kodera, Yoshio, Tsuji, Takashi, Ma, Jian-Xing, Sakai, Tatsuo, Matsumoto, Hiroyuki, Obara, Tomoko]
通讯作者:
Obara, Tomoko
HHM(Maid) is a specific regulator to inhibit the generation of liver tumor and progression of liver fibrosis-From the studyof CCl4 induced Maid KO mice and DEN exposure HHM Tg medaka fish-
HHM(Maid)是抑制肝肿瘤生成和肝纤维化进展的特异性调节剂-来自CCl4诱导Maid KO小鼠和DEN暴露HHM Tg青鳉鱼的研究-
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Shuji Terai, Naoki Yamamoto, Koichi Fujisawa, Tomoaki Murata, Isao Sakaida]
通讯作者:
Isao Sakaida
DOI:
10.1016/j.bbrc.2012.04.087
发表时间:
2012-05
期刊:
Biochemical and biophysical research communications
影响因子:
3.1
作者:
[Toshiyuki Oishi;S. Terai;Shinya Kuwashiro;K. Fujisawa;Toshihiko Matsumoto;H. Nishina;I. Sakaida]
通讯作者:
Toshiyuki Oishi;S. Terai;Shinya Kuwashiro;K. Fujisawa;Toshihiko Matsumoto;H. Nishina;I. Sakaida
メダカおよびマウスを用いた非アルコール性脂肪肝炎の病態研究および薬物スクリーニング
青鳉和小鼠非酒精性脂肪性肝炎的病理学研究及药物筛选
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Sugimura K, Fukumoto Y, Satoh K, Nochioka K, Miura Y, Aoki T, Tatebe S, Miyamichi-Yamamoto S, Shimokawa H, 寺井 崇二]
通讯作者:
寺井 崇二
共 6 条
Basic research to develop next generation cell therapy for improvement of liver fibrosis.
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批准号:26293175
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.65万
-
财政年份:2014
-
负责人:TERAI Shuji
-
依托单位:
The basic research of the development of future generation cell therapy used bone marrow derived liver repaid cell
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批准号:22390150
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.98万
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财政年份:2010
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负责人:TERAI Shuji
-
依托单位:
Basic studies for the development of efficient liver regenerative therapy using bone marrow cells
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批准号:18590737
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.57万
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财政年份:2006
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负责人:TERAI Shuji
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依托单位:
海外基金