The basic research of the development of future generation cell therapy used bone marrow derived liver repaid cell

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Our researches showed that autologous bone marrow derived cells (BMCs) were useful for liver regeneration therapy for liver cirrhosis. In these projects, we estimated characterization of bone marrow derived liver repair cells and demonstrated the mechanisms of liver repair by BMCs. We found that macrophage was effective to improve liver fibrosis in mice. In this project, we found that TNF signal is important to induce liver repair by BMC infusions. We found that bone marrow derived mesenchymal cells might be a new candidate-cell-fraction to repair liver fibrosis. Both TNF and Maid signal are important to regulate improvement of liver fibrosis by BMC infusion. These results are important to develop a new cell therapy using BMCs.