Analysis of expression of Melanopsin in human skin

检测黑视素在人皮肤中的表达。其表达的定位为；表皮中的角质细胞，黑素细胞，真皮中的成纤维细胞。450nm LED光照射引起ERK磷酸化上调，磷酸化程度与照射时间有关。另一方面，570nm光照射引起ERK磷酸化下调。两种光的照射使ERK磷酸化程度增加。

The expression of Melanopsin in human skin were detected. The localization of its expression were; keratinocyte, melanocyte in epidermis, fibroblast in dermis. Irradiation of 450nm of LED light cause the up regulation of phosphorylation of ERK and degree of phosphorylation were related to the irradiation time. On the other hand, irradiation of 570nm light cause the down regulation of phosphorylation of ERK.Irradiation of both lights causes the more phosphorylation of ERK.