Development of Intelligent Gadorinium Neutron Capture Therapy asCancer Specific Atomic Suppression Therapy

用钆（Gd）包封的脂质体和热中子照射（5 x 10^12 n/cm^2）（Gd中子捕获疗法）治疗显示结肠26肿瘤生长抑制。我们制备了由聚乙烯亚胺（PEI）、含羧酸的聚乙二醇衍生物（PEG-C）和JTS-1（融合肽）组成的Gd混合络合物，瘤内注射后2小时/ 12小时的Gd浓度为21.9 /12.3ppm。Gd的浓度比对照组高2倍。1.96mg钆特醇对X线照射的细胞毒作用抑制率为29%。

The Colon 26 tumour growth suppression was revealed in treated with gadolinium (Gd)-entrapped liposome with thermal neutron irradiation(5 x 10^12 n/cm^2) (Gd Neutron Capture Therapy). We prepared Gd mixed complex consisted with polyethyleneimine (PEI), polyethylene glycol derivatives having carboxylic acid (PEG-C), and JTS-1 (fusogenic peptide), and the Gd concentration in 2 hours / 12 hours after intratumoral injection are 21.9 / 12.3 ppm. The concentration of Gd is two times highed compared with the control group. The cytotoxic effect was showed 29% suppression by 1.96-mg of Gadteridol with X ray irradiation.