The effect of IL-18 and gender difference on inflammation-related insulin resistance.

本研究的目的是评估内源性IL-18及其性别差异对炎症相关胰岛素抵抗的影响。内源性IL-18可能抑制急性炎症时的高血糖和高胰岛素血症。雄性小鼠血浆胰岛素浓度高于雌性小鼠，但IL-18与这种性别差异的关系尚不清楚。内源性IL-18在炎症相关胰岛素抵抗性别差异中的作用有待进一步研究。

The purpose of this study was to evaluate the effects of endogenous IL-18 and its gender difference on inflammation-related insulin resistance. The endogenous IL-18 might inhibit hyperglycemia and hyperinsulinemia during acute inflammation. The plasma insulin concentration was higher in male than in female mice, however, the relation of IL-18 to this gender differencve has not been elucidated clearly yet. Further studies are needed to investigate the role ofendogenous IL-18 on the gender difference in inflammation-related insulin resistance.