Elucidation of cell fate determination mechanism of pancreatic endocrine cells using in vivo imaging
Elucidation of cell fate determination mechanism of pancreatic endocrine cells using in vivo imaging
批准号:
24650228
负责人:
TAKAHASHI Satoru
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31
中文摘要
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英文摘要
In this study, it is intended to make clear that the fluctuation of the cell fate of pancreatic beta cells is one of the mechanisms of diabetes progression. We also want to reveal that the plasticity of pancreatic endocrine cells associated with the instability is related to insulin resistance and a precipitating factor for the disease. To this end, We want to establish evaluation systems using animal model a new real-time imaging techniques.
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Novel ROSA26 Cre-reporter knock-in C57BL/6N mice exhibiting green emission before and red emission after Cre-mediated recombination
新型 ROSA26 Cre 报告基因敲入 C57BL/6N 小鼠在 Cre 介导的重组前表现出绿色发射,在 Cre 介导的重组后表现出红色发射
DOI:
--
发表时间:
2013
期刊:
Exp Animal
影响因子:
--
作者:
[Hasegawa Y, Daitoku Y, Sekiguchi K, Tanimoto Y, Iijima S, Mizuno S, Kajiwara N, Ema M, Miwa Y, Mekada K, Yoshiki A, Takahashi S, Sugiyama F, Yagami K-I]
通讯作者:
Yagami K-I
In vivo monitoring of pancreatic β-cell mass and intrahepatic insulin gene activity in Ins1-luc BAC transgenic mice by bioluminescence imaging.
通过生物发光成像体内监测 Ins1-luc BAC 转基因小鼠的胰腺 β 细胞质量和肝内胰岛素基因活性。
DOI:
--
发表时间:
2013
期刊:
Plos One
影响因子:
3.7
作者:
[Katsumata T, Oishi H, Sekiguchi Y, Nagasaki H, Daassi D, Ema M, Kudo T, Takahashi S.]
通讯作者:
Takahashi S.
膵内分泌細胞の発生・分化における大Maf群転写因子の役割
大Maf组转录因子在胰腺内分泌细胞发育和分化中的作用
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[大石久史, 高橋 智]
通讯作者:
高橋 智
DOI:
10.1538/expanim.63.183
发表时间:
2014
期刊:
Experimental animals
影响因子:
2.4
作者:
[Hasegawa Y, Daitoku Y, Mizuno S, Tanimoto Y, Mizuno-Iijima S, Matsuo M, Kajiwara N, Ema M, Oishi H, Miwa Y, Mekada K, Yoshiki A, Takahashi S, Sugiyama F, Yagami K]
通讯作者:
Yagami K
筑波大学 解剖学・発生学研究室
筑波大学解剖学与胚胎学实验室
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
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