Analysis of endocrine-related protein involved in prostate cell growth

前列腺细胞生长相关内分泌相关蛋白的分析

• 批准号: 20591869
• 负责人: TAKAHASHI Satoru
• 金额: $ 2.91万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591869/
• 关键词: 腫瘍学; ゲノム; 前立腺癌; Androgen; 2011; 10; 01; ACSL3; ARFGAP3; 前立腺; Oct1; アンドロゲンレセプター; Amyloid Precursor Protein; アンドロゲン; エストロゲン; estrogen-related receptors; estrogen receptor-binding fragment-associated gene 9; ETS family; Oct-1; androgen; e

(1) We demonstrated the differential expression of estrogen receptor-related protein in prostate cancer. (2) We evaluated CYP3A4 expression in human prostrate cancer tissues. (3) We identified amyloid precursor protein and ARFGAP3 as a primary androgen targetandrogen target genes that are directly regulated by AR in LNCaP cells, by combining chromatin immunoprecipitation (ChIP) with tiling micro-arrays (ChIP-chip). (4) We identified Oct1 correlates with the poorer survival prognosis of the prostate cancer patients.

(1)我们证实了雌激素受体相关蛋白在前列腺癌中的差异表达。(2)我们检测了CYP3A4在人前列腺癌组织中的表达。(3)结合染色质免疫沉淀（ChIP）和贴片微阵列（ChIP- ChIP）技术，我们在LNCaP细胞中发现淀粉样蛋白前体蛋白和ARFGAP3是受AR直接调控的雄激素靶基因。(4)我们发现Oct1与前列腺癌患者较差的生存预后相关。

项目成果

ARFGAP3 is an androgen-responsive gene that positively promotes proliferation in prostate cancer cell line.

ARFGAP3 是一种雄激素反应基因，可积极促进前列腺癌细胞系的增殖。

• 发表时间: 2009
• 作者: 大日方大亮;高山賢一;浦野友彦;堀江公仁子;池田和博;大内尉義;高橋悟;井上聡;大日方大亮
• 通讯作者: 大日方大亮

Differential expression of estrogen-related receptors β and γ (ERRβ and ERRγ) and their clinical significance in human prostate cancer

• DOI: 10.1111/j.1349-7006.2009.01451.x
• 发表时间: 2010-03-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Fujimura, Tetsuya;Takahashi, Satoru;Inoue, Satoshi
• 通讯作者: Inoue, Satoshi

Differential expression of estrogen-related receptors beta and gamma (ERRbeta and ERRgamma) and their clinical significance in human prostate cancer

雌激素相关受体β和γ（ERRbeta和ERRgamma）的差异表达及其在人类前列腺癌中的临床意义

• 发表时间: 2010
• 期刊: Cancer Sci 101
• 作者: Meshima;K.;石原宏;Ikeda K;Fujimura T
• 通讯作者: Fujimura T

Expression of Cytochrome P450 3A4 and Its Clinical Significance in Human Prostate Cancer

• DOI: 10.1016/j.urology.2009.02.033
• 发表时间: 2009-08-01
• 期刊: UROLOGY
• 影响因子: 2.1
• 作者: Fujimura, Tetsuya;Takahashi, Satoru;Inoue, Satoshi
• 通讯作者: Inoue, Satoshi

Oct1 regulates cell growth of LNCaP cells and is a prognostic factor for prostate cancer

• DOI: 10.1002/ijc.26043
• 发表时间: 2012-03-01
• 期刊: INTERNATIONAL JOURNAL OF CANCER
• 影响因子: 6.4
• 作者: Obinata, Daisuke;Takayama, Ken-ichi;Inoue, Satoshi
• 通讯作者: Inoue, Satoshi