cryoimmunotherapy for malignant bone tumors

恶性骨肿瘤的冷冻免疫治疗

• 批准号: 24650631
• 负责人: TSUCHIYA Hiroyuki
• 金额: $ 2.41万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24650631/
• 关键词: 凍結免疫; 凍結免疫療法; 骨軟部腫瘍; 免疫

The purpose of this study is that the cryotreatment of tumor tissue may induced anti tumor effect, and that suppressed tumor recurrence and metastases. We have treated 25 patients for malignant tumors who failed standard treatment of surgery, chemotherapy, and radiotherapy. Then we started dendritic cell immunotherapy generated extra vivo, which pulsed with cryotreated tumor tissue mixed with OK-432. 3o% of patients induced immunological reactions. After that, we planed that the patients treated by cry treatment using liquid nitrogen combined with dendritic cell immunotherapy to reduce local recurrence and metastasis.

本研究的目的是探讨冷冻治疗肿瘤组织可能产生的抗肿瘤作用，并抑制肿瘤的复发和转移。我们已经治疗了25例恶性肿瘤患者，这些患者在手术、化疗和放疗的标准治疗中失败。然后，我们开始体外产生树突状细胞免疫治疗，其用与OK-432混合的冷冻处理的肿瘤组织进行脉冲。30%的患者出现免疫反应。在此之后，我们计划对患者进行液氮冷冻治疗联合树突状细胞免疫治疗，以减少局部复发和转移。

项目成果

Immunotherapy based on dendritic cells is feasible for patients with malignant bone and soft tissue tumours

基于树突状细胞的免疫疗法对于恶性骨和软组织肿瘤患者是可行的

• 发表时间: 2013
• 作者: Hideji Nishida;Norio Yamamoto;Akihiko Takeuchi;Yoshikazu Tanzawa;Hiroaki Kimura;Munetomo Takata;Isei Nomura;Shinji Miwa;Takashi Kato;Hiroyuki Tsuchiya
• 通讯作者: Hiroyuki Tsuchiya

腫瘍再建術の最前線

肿瘤重建手术的最前沿

• 发表时间: 2012
• 作者: Hideji Nishida;Yoshikazu Tanzawa;Norio Yamamoto;Katsuhiro Hayashi;Akihiko Takeuchi;Hiroaki Kimura;Shingo Shimozaki;Hiroyuki Tsuchiya;土屋弘行;Tsuchiya H;Tsuchiya H;土屋弘行;土屋弘行
• 通讯作者: 土屋弘行

Biological limb reconstruction for tumor surgery

肿瘤手术生物肢重建

• 发表时间: 2012
• 作者: Hideji Nishida;Yoshikazu Tanzawa;Norio Yamamoto;Katsuhiro Hayashi;Akihiko Takeuchi;Hiroaki Kimura;Shingo Shimozaki;Hiroyuki Tsuchiya;土屋弘行;Tsuchiya H
• 通讯作者: Tsuchiya H

Controversy of orthopedic oncology: Biological reconstruction

骨科肿瘤学争议：生物重建

• 发表时间: 2013
• 作者: Hideji Nishida;Norio Yamamoto;Akihiko Takeuchi;Yoshikazu Tanzawa;Hiroaki Kimura;Munetomo Takata;Isei Nomura;Shinji Miwa;Takashi Kato;Hiroyuki Tsuchiya;Tsuchiya H
• 通讯作者: Tsuchiya H

ここまで来た骨腫瘍再建術

骨肿瘤重建已经走到了这一步

• 发表时间: 2012
• 作者: Hideji Nishida;Yoshikazu Tanzawa;Norio Yamamoto;Katsuhiro Hayashi;Akihiko Takeuchi;Hiroaki Kimura;Shingo Shimozaki;Hiroyuki Tsuchiya;土屋弘行
• 通讯作者: 土屋弘行