cryoimmunotherapy for malignant bone tumors

本研究的目的是通过对肿瘤组织的冷冻处理，发挥抗肿瘤作用，抑制肿瘤的复发和转移。我们已经治疗了25例手术、化疗和放射治疗失败的恶性肿瘤患者。然后我们开始用体外产生的树突状细胞免疫疗法，用冷冻处理的肿瘤组织与OK-432混合脉冲。30%的患者可引起免疫反应。之后，我们计划用液氮联合树突状细胞免疫治疗来减少局部复发和转移。

The purpose of this study is that the cryotreatment of tumor tissue may induced anti tumor effect, and that suppressed tumor recurrence and metastases. We have treated 25 patients for malignant tumors who failed standard treatment of surgery, chemotherapy, and radiotherapy. Then we started dendritic cell immunotherapy generated extra vivo, which pulsed with cryotreated tumor tissue mixed with OK-432. 3o% of patients induced immunological reactions. After that, we planed that the patients treated by cry treatment using liquid nitrogen combined with dendritic cell immunotherapy to reduce local recurrence and metastasis.