Investigation of the effect of retinoids on hepatic iron overload in a mouse NAFLD model.
Investigation of the effect of retinoids on hepatic iron overload in a mouse NAFLD model.
批准号:
21790666
负责人:
TSUCHIYA Hiroyuki
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
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英文摘要
Hepatic iron overload in non-alcoholic fatty liver disease (NAFLD) patients with steatosis and insulin resistance has been frequently observed in clinical settings. In this study, I found the close association between the iron overload and aberrant lipid deposition in the liver. Since I have previously clarified that retinoids have a potent effect on the hepatic iron metabolism, the pathological effect of a retinoid in mice with NAFLD was investigated. Consequently, the retinoid was found to markedly improve the insulin resistance in the mouse model in a leptin-dependent manner.
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DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
DOI:
10.1111/j.1872-034x.2010.00719.x
发表时间:
2010-12
期刊:
Hepatology Research
影响因子:
4.2
作者:
[H. Tsuchiya;An Afida Ashla;Y. Hoshikawa;Yoshiaki Matsumi;K. Kanki;M. Enjoji;S. Momosaki;M. Nakamuta;A. Taketomi;Y. Maehara;K. Shomori;A. Kurimasa;I. Hisatome;Hisao Ito;G. Shiota]
通讯作者:
H. Tsuchiya;An Afida Ashla;Y. Hoshikawa;Yoshiaki Matsumi;K. Kanki;M. Enjoji;S. Momosaki;M. Nakamuta;A. Taketomi;Y. Maehara;K. Shomori;A. Kurimasa;I. Hisatome;Hisao Ito;G. Shiota
レチノイン酸受容体リガンドによるインスリン抵抗性改善作用
通过视黄酸受体配体改善胰岛素抵抗
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[]
通讯作者:
A close association of abnormal iron metabolism with steatosis in the mice fed a choline-deficient diet
缺乏胆碱饮食的小鼠铁代谢异常与脂肪变性密切相关
DOI:
--
发表时间:
2010
期刊:
Biological & Pharmaceutical Bulletin 33
影响因子:
--
作者:
[土谷博之, 他]
通讯作者:
他
レチノイン酸によるレプチン依存的インスリン抵抗性改善作用
视黄酸改善瘦素依赖性胰岛素抵抗的作用
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[土谷博之, 他]
通讯作者:
他
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