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Genome-wide in vivo footprinting by next-generation sequencing

Genome-wide in vivo footprinting by next-generation sequencing
通过新一代测序进行全基因组体内足迹
批准号：
24651226
负责人：
ITO Takashi
金额：
$2.58万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Challenging Exploratory Research
财政年份：
2012
资助国家：
日本
项目状态：
已结题
起止时间：
2012-04-01 至 2013-03-31
来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24651226/
关键词：
ゲノム解析技術クロマチン構造in vivoフットプリンティングジメチル硫酸高感受性部位

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英文摘要
Proteins that act on genomic DNA functionally regulate the genome. Accordingly, if we can comprehensively reveal the interactions between genomic DNA and proteins in living cells, we will substantially deepen our understanding of how the genome works. As a novel method toward this goal, we tried to develop a method termed DMS-Seq that uses dimethylsulfate (DMS) and next-generation sequencing. Following the optimization of the method, we applied it to the baker's yeast as a model system and successfully detected signals on regions known to regulate gene expression. These results would suggest the feasibility of this approach.
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