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Genome-wide analysis of chromatin structure at single molecule resolution by base modification and next-generation sequencing

Genome-wide analysis of chromatin structure at single molecule resolution by base modification and next-generation sequencing
通过碱基修饰和新一代测序以单分子分辨率对染色质结构进行全基因组分析
批准号：
23651199
负责人：
ITO Takashi
金额：
$2.58万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Challenging Exploratory Research
财政年份：
2011
资助国家：
日本
项目状态：
已结题
起止时间：
2011 至 2012
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23651199/
关键词：
クロマチン構造次世代シーケンサ次世代シーケンスクロマチン修飾酵素プロービング

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中文摘要
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英文摘要
To improve our understanding of chromatin dynamics, we have to reveal linkage/association among nucleosome/transcription factor?DNA interactions. Toward this goal, we tried to develop a novel method that utilizes base modifications, but not DNA cleavage, to reveal chromatin structure in a genome-wide scale. While a similar method termed NOME-Seq was reported, its combined use with PBAT, a bisulfite sequencing method of our own, would enable a practical and highly-sensitive analysis.
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会议论文
Amplification-free whole-genome bisulfite sequencing by post-bisulite adaptor tagging
通过亚硫酸氢盐后接头标记进行无扩增全基因组亚硫酸氢盐测序
DOI： --
发表时间： 2012
期刊： Nucleic Acids Res
影响因子： 14.9
作者： [Fumihito Miura, Yusuke Enomoto, Ryo Dairiki and Takashi Ito]
通讯作者： Ryo Dairiki and Takashi Ito
A novel therapeutic strategy targeting HMGB1 isoforms in sepsis
  • 批准号：
    18H02904
  • 项目类别：
    Grant-in-Aid for Scientific Research (B)
  • 资助金额：
    $11.15万
  • 财政年份：
    2018
  • 负责人：
    ITO Takashi
  • 依托单位：
    Kagoshima University
A Comprehensive Analysis of Direct Democracy in the Case of Local Government and Referendums in Osaka through Repeated Cross-sectional Surveys
Chromatin remodeling and Induction of pluripotency via Sox2/TBP complex
  • 批准号：
    17H04044
  • 项目类别：
    Grant-in-Aid for Scientific Research (B)
  • 资助金额：
    $11.4万
  • 财政年份：
    2017
  • 负责人：
    ITO Takashi
  • 依托单位：
    Nagasaki University
Helicobacter pylori induces somatic mutations in TP53 via overexpression of CHAC1 in infected gastric epithelial cells
  • 批准号：
    16K19077
  • 项目类别：
    Grant-in-Aid for Young Scientists (B)
  • 资助金额：
    $2.5万
  • 财政年份：
    2016
  • 负责人：
    ITO Takashi
  • 依托单位：
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