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Transomic analysis of adaptation induced by a synthetic gene circuit

Transomic analysis of adaptation induced by a synthetic gene circuit
合成基因回路诱导适应的转染色体分析
批准号：
25640110
负责人：
ITO Takashi
金额：
$2.58万
依托单位：
Kyushu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Challenging Exploratory Research
财政年份：
2013
资助国家：
日本
项目状态：
已结题
起止时间：
2013-04-01 至 2014-03-31
来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-25640110/
关键词：
人工遺伝子回路トランスオミクス適応ヒストンメチル化ミトコンドリアレトロトランスポゾンSAM

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英文摘要
The cell can adapt to various environmental changes and stably inherit the adapted states to the daughter cells. It has been long argued that such adaptation stems from the plasticity of gene circuits and that mutations play a role in fixation of the state in the population. We used a synthetic gene circuit to expose yeast cells to a selection pressure and found that they can stably maintain an adapted state even after its withdrawal. To address the mechanism underlying this phenomenon, we took a transomic analysis that integratively examines the layers of the genome DNA, chromatin, and RNAs, and revealed evidence for potential involvement of movable genetic elements, histone modifications and mitochondria.
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会议论文
人工遺伝子回路によって誘導される適応現象のトランスオミクス解析
人工基因电路引起的适应性现象的跨组学分析
DOI： --
发表时间： 2013
期刊：
影响因子： --
作者： [梅山大地, 伊藤隆司]
通讯作者： 伊藤隆司
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    18H02904
  • 项目类别：
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  • 资助金额：
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  • 资助金额：
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