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Time matters: Integration of time information into memory processes

时间很重要：将时间信息整合到记忆过程中

基本信息

批准号：
394824213
负责人：
Privatdozent Dr. Dennis Pauls
金额：
--
依托单位：
Arbeitsgruppe Tierphysiologie
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2018
资助国家：
德国
起止时间：
2017-12-31 至 2021-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/394824213?language=en
关键词：
Time matters Integration time information

项目摘要

In 2014 John O´Keefe, May-Britt Moser and Edvard I. Moser were honored with the Nobel Prize in Physiology and Medicine for their work on cells that constitute a positioning system in the brain. Special cells, place and grid cells, enable the brain to orientate within the environment, allowing us to know where we are, how to navigate from one place to another and to form and express spatial memories. For animals both spatial navigation and spatial memories are essential to enhance fitness and survival based on the timely relocation of food sources and mating partners and the avoidance of predators which often establish typical hunting routes. But how are the circadian clock and memory circuits connected? A recent study illustrated for the first time that Drosophila is able to form time-related odor-sugar memories, where flies learn that one odor is coupled to reward in the morning while a second odor to the same reward in the afternoon. As a result of this finding Drosophila now appears to be a suitable model system to identify the neuronal correlates underlying time-related memories. I will address where in the brain these memories are stored and how time information delivered by clock neurons is integrated in memory circuits. On top, my aim is to unravel whether flies can link time to spatial information in order to form time-place memories, which are well-known in invertebrate (bees, ants) and vertebrate species (rats, mice). This would allow for the first time to identify the neuronal correlates enabling animals to be in the right place at the right time.

2014年，John O'Keefe，May-Britt Moser和Edvard I。莫泽被授予诺贝尔生理学和医学奖，以表彰他们对构成大脑定位系统的细胞的研究。特殊的细胞，位置和网格细胞，使大脑能够在环境中定位，让我们知道我们在哪里，如何从一个地方导航到另一个地方，并形成和表达空间记忆。对于动物来说，空间导航和空间记忆对于提高健康和生存至关重要，这是基于及时重新定位食物来源和交配伙伴以及避免通常建立典型狩猎路线的捕食者。但是生物钟和记忆回路是如何联系的呢？最近的一项研究首次表明，果蝇能够形成与时间相关的气味-糖记忆，其中苍蝇学习到一种气味在早上与奖励相关联，而第二种气味在下午与相同的奖励相关联。由于这一发现，果蝇现在似乎是一个合适的模型系统，以确定神经元相关的时间相关的记忆。我将讨论这些记忆在大脑中的存储位置，以及时钟神经元传递的时间信息如何整合到记忆回路中。最重要的是，我的目标是解开苍蝇是否可以将时间与空间信息联系起来，以形成时间-地点记忆，这在无脊椎动物（蜜蜂，蚂蚁）和脊椎动物物种（大鼠，小鼠）中是众所周知的。这将首次允许识别神经元相关性，使动物能够在正确的时间出现在正确的地方。