Neurobiological basis of the integration of time in memories

记忆中时间整合的神经生物学基础

• 批准号: 504082293
• 负责人: Privatdozent Dr. Dennis Pauls
• 金额: --
• 依托单位: Arbeitsgruppe Tierphysiologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/504082293?language=en
• 关键词: Neurobiological; basis; integration; time; memories

Specific memories enable humans and animals to store important information. The memory trace is based on synaptic plasticity, i.e. changes in synaptic connections or transmission between participating neurons. In addition to accurate memory formation, precise retrieval of stored information is also of utmost importance. Only when information is stored accurately and retrieved at the right time, a memory provides the expected benefits. Not only for humans, but perhaps especially in the animal kingdom, it is important to be in the right place at the right time. To do this, experiences must be encoded in time and space so that a particular place can be visited or avoided at the right time based on this memory. Specifically, animals have to avoid unpleasant or dangerous situations or find food and synchronise with reciprocal interaction partners. Time, in particular, plays a crucial role in this process, as many environmental features, especially the availability of food, show rhythmic changes during the day. Therefore, the integration of time in memories is of utmost importance to accurately remember a biologically significant event. We aim to combine high-resolution behavioural experiments, light microscopic and electron microscopic analyses, and live cell imaging (Ca2+ and FRET imaging) to identify the neuronal networks that allow time information, e.g. the time of day, to be integrated into the memory trace.

特定的记忆使人类和动物能够储存重要的信息。记忆痕迹基于突触可塑性，即参与神经元之间突触连接或传输的变化。除了准确的记忆形成之外，对存储信息的精确检索也是至关重要的。只有当信息被准确地存储并在正确的时间检索时，记忆才能提供预期的好处。不仅对人类，而且可能特别是在动物王国，在正确的时间出现在正确的地方是很重要的。要做到这一点，经验必须在时间和空间中编码，以便根据这种记忆在正确的时间访问或避免特定的地方。具体来说，动物必须避免不愉快或危险的情况或寻找食物，并与互惠互动伙伴同步。特别是时间在这一过程中起着至关重要的作用，因为许多环境特征，特别是食物的供应，在一天中表现出有节奏的变化。因此，记忆中时间的整合对于准确记住具有生物学意义的事件至关重要。我们的目标是结合联合收割机高分辨率的行为实验，光学显微镜和电子显微镜分析，和活细胞成像（钙离子和FRET成像），以确定神经网络，允许时间信息，例如，一天中的时间，被整合到记忆痕迹。