Change of telomere length by stress

压力引起的端粒长度变化

• 批准号: 24657008
• 负责人: ISHII Shunsuke
• 金额: $ 2.58万
• 依托单位: The Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24657008/
• 关键词: テロメア; ストレス; ATF-7

It was reported that various stresses including psychological stress shorten the telomere length. This suggests the possibility that psychological stress affects longevity. However, due to its unknown mechanism, this has not yet been generally accepted. We have shown that a stress-responsive transcription factor ATF-7, a member of ATF-2 family transcription factors, contributes to the stress-induced telomere shortening.

据报道，包括心理应激在内的各种应激都会缩短端粒长度。这表明心理压力可能影响寿命。然而，由于其未知的机制，这尚未被普遍接受。我们已经证明，胁迫响应转录因子ATF-7，ATF-2家族转录因子的成员，有助于胁迫诱导的端粒缩短。

项目成果

転写因子ATF-7を介したストレスによるテロメアの長さの制御

应激通过转录因子 ATF-7 调节端粒长度

• 发表时间: 2012
• 作者: 前川利男,劉彬彬;吉田圭介;仲村賢一;田久保海誉;石井俊輔
• 通讯作者: 石井俊輔

Su(fu) switches Rdx functions to fine-tune hedgehog signaling in the Drosophila wing disk

Su(fu)切换Rdx功能以微调果蝇翼盘中的hedgehog信号

• DOI: 10.1111/gtc.12018
• 发表时间: 2013
• 期刊: Genes Cells
• 影响因子: 2.1
• 作者: Kondo H;Kusaka S;Yoshinaga A;Uchio E;Tawara A;Tahira T;松本経;大塚俊之;Seong KH & Ishii S
• 通讯作者: Seong KH & Ishii S

マクロファージの炎症時におけるATF-7の機能解析

ATF-7在巨噬细胞炎症过程中的功能分析

• 发表时间: 2012
• 作者: 吉田圭介;前川利男;Renard-Guillet Claire;白髭克彦;石井俊輔
• 通讯作者: 石井俊輔

Fbxw5 suppresses nuclear c-Myb activity via DDB1-Cul4-Rbx1 ligase-mediated sumoylation

• DOI: 10.1016/j.bbrc.2012.08.032
• 发表时间: 2012-09-14
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Kanei-Ishii, Chie;Nomura, Teruaki;Ishii, Shunsuke
• 通讯作者: Ishii, Shunsuke

Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia.

• DOI: 10.1038/npp.2013.38
• 发表时间: 2013-07
• 期刊: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology