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Research on signal transduction via transcriptional mediators

Research on signal transduction via transcriptional mediators
转录介质信号转导研究
批准号：
23370079
负责人：
ISHII Shunsuke
金额：
$12.81万
依托单位：
The Institute of Physical and Chemical Research
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2011
资助国家：
日本
项目状态：
已结题
起止时间：
2011-04-01 至 2014-03-31
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23370079/
关键词：
転写メディエーターシグナル伝達転写アダプターTRIM27Shn-2転写制御メディエーター転写T細胞分化アポトーシス

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中文摘要
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英文摘要
We found that corepressor Ski binds to TRIM27, and that TRIM27 contributes to deubiquitination via forming a complex with USP7. It was found that TRIM27 enters into the nucleus in response to poly(I-C) stimulation, suggesting that Ski ubiquitination may be regulated by TRIM27 in response to specific signaling.In knockout mice of transcriptional adaptor Shn-2, T cell differentiation in thymus is blocked. It was found that Shn-2 is modified by O-GlcNAc at several sites which modulates nuclear entry of Shn-2. It was demonstrated that Shn-2 is localized on the T-cell receptor beta gene locus, and modulated allelic exclusion.
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会议论文
Ubiquitination-deubiquitination by the TRIM27-USP7 complex regulates TNF-α-induced apoptosis
TRIM27-USP7 复合物的泛素化-去泛素化调节 TNF-α 诱导的细胞凋亡
DOI： --
发表时间： 2013
期刊：
影响因子： --
作者： [Zaman MM, Ishii S 他]
通讯作者： Ishii S 他
Inheritance of stress-induced epigenome change : research using fly and mouse
应激引起的表观基因组变化的遗传：使用果蝇和小鼠的研究
DOI： --
发表时间： 2011
期刊：
影响因子： --
作者： [Staton TL, Lazarevic V, Jones DC, Lanser AJ, Takagi T, Ishii S, Glimcher LH, 石井俊輔]
通讯作者： 石井俊輔
Ubiquitination-deubiquitination by the TRIM27-USP7 complex regulates TNF- α-induced apoptosis
TRIM27-USP7 复合物的泛素化-去泛素化调节 TNF-α 诱导的细胞凋亡
DOI： --
发表时间： 2013
期刊：
影响因子： --
作者： [Zaman MM, Nomura T, Takagi T, Okamura T, Jin W, Shinagawa T, Tanaka Y, Ishii S]
通讯作者： Ishii S
Inheritance of Stress-Induced, ATF-2-Dependent Epigenetic Change
DOI： 10.1016/j.cell.2011.05.029
发表时间： 2011-06-24
期刊： CELL
影响因子： 64.5
作者： [Seong, Ki-Hyeon, Li, Dong, Ishii, Shunsuke]
通讯作者： Ishii, Shunsuke
共 29 条
    Change of telomere length by stress
    Regulation of metabolism and cellular proliferation by virus infection
    Research on transcriptional mediators regulated by signals
    Transcriptional control by mediators and their physiological significance
    海外基金