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Research on transcriptional mediators regulated by signals

Research on transcriptional mediators regulated by signals
信号调控转录介质的研究
批准号:
20370074
负责人:
ISHII Shunsuke
金额:
$13.06万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

项目摘要

项目成果

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中文摘要
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英文摘要
We found that the Ski corepressor complex contained Smad2/3/4, histone deacetylase HDAC3, and protein arginine N-methyltransferase PRMT5. This suggests that Ski binds to the TGF-β/BMP target genes to keep their low basal transcription levels via HDAC3 and PRMT5. We also showed that Shn-2 adaptor protein has a role to maintain cellular proliferation via suppressing apoptosis during T cell development.
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会议论文
DOI: 10.1002/jnr.21510
发表时间: 2008-02
期刊: Journal of Neuroscience Research
影响因子: 4.2
作者: [M. Kojima;Takahiro Suzuki;T. Maekawa;S. Ishii;C. Sumi-Ichinose;T. Nomura;H. Ichinose]
通讯作者: M. Kojima;Takahiro Suzuki;T. Maekawa;S. Ishii;C. Sumi-Ichinose;T. Nomura;H. Ichinose
DOI: 10.1111/j.1365-2443.2008.01165.x
发表时间: 2008-03-01
期刊: GENES TO CELLS
影响因子: 2.1
作者: [Shimada, Nobukazu, Shinagawa, Toshie, Ishii, Shunsuke]
通讯作者: Ishii, Shunsuke
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [成耆鉉, 志水英之, 野村照明, 石井俊輔]
通讯作者: 石井俊輔
DOI: 10.1038/nature09848
发表时间: 2011-04-07
期刊: NATURE
影响因子: 64.8
作者: [Staton, Tracy L., Lazarevic, Vanja, Jones, Dallas C., Lanser, Amanda J., Takagi, Tsuyoshi, Ishii, Shunsuke, Glimcher, Laurie H.]
通讯作者: Glimcher, Laurie H.
40
    Change of telomere length by stress
    Regulation of metabolism and cellular proliferation by virus infection
    Research on signal transduction via transcriptional mediators
    Transcriptional control by mediators and their physiological significance
    海外基金