Regulation of metabolism and cellular proliferation by virus infection

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TNF-α, which induces inflammatory mediators and apoptosis, is induced by pathogen infection, and is involved in pathogen protection. We have identified new TRIM protein that functions in the TNF-αsignaling pathway. In the liver lacking this TRIM protein, the levels of genes that are involved in the biosynthesis of cholesterol and lipid are increased. This suggests that this TRIM protein is involved in the regulation of metabolism as well as in the pathogen protection via regulating the TNF-αsignaling pathway. Thus, the key regulator that links the immune system and metabolism has been identified.