Regulation of metabolism and cellular proliferation by virus infection

病毒感染对新陈代谢和细胞增殖的调节

• 批准号: 23659244
• 负责人: ISHII Shunsuke
• 金额: $ 2.58万
• 依托单位: The Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659244/
• 关键词: ウイルス感染; 代謝; 細胞増殖; TNF-α; 免疫系; 代謝系; リンケージ; TRIM; コレステロール

TNF-α, which induces inflammatory mediators and apoptosis, is induced by pathogen infection, and is involved in pathogen protection. We have identified new TRIM protein that functions in the TNF-αsignaling pathway. In the liver lacking this TRIM protein, the levels of genes that are involved in the biosynthesis of cholesterol and lipid are increased. This suggests that this TRIM protein is involved in the regulation of metabolism as well as in the pathogen protection via regulating the TNF-αsignaling pathway. Thus, the key regulator that links the immune system and metabolism has been identified.

TNF-α可诱导炎症介质和细胞凋亡，受病原体感染诱导，参与病原体保护。我们发现了在TNF-α信号通路中起作用的新TRIM蛋白。在缺乏这种TRIM蛋白的肝脏中，参与胆固醇和脂质生物合成的基因水平会增加。这表明该TRIM蛋白通过调节TNF-α信号通路参与代谢调节和病原体保护。因此，连接免疫系统和新陈代谢的关键调节因子已经被确定。

项目成果

Inheritance of Stress-Induced, ATF-2-Dependent Epigenetic Change

• DOI: 10.1016/j.cell.2011.05.029
• 发表时间: 2011-06-24
• 期刊: CELL
• 影响因子: 64.5
• 作者: Seong, Ki-Hyeon;Li, Dong;Ishii, Shunsuke
• 通讯作者: Ishii, Shunsuke

Inheritance of stress-induced epigenome change : research using fly and mouse

应激引起的表观基因组变化的遗传：使用果蝇和小鼠的研究

• 发表时间: 2011
• 作者: Staton TL;Lazarevic V;Jones DC;Lanser AJ;Takagi T;Ishii S;Glimcher LH;石井俊輔
• 通讯作者: 石井俊輔

ストレスによるエピゲノム変化とその遺伝

压力引起的表观基因组变化及其遗传

• 发表时间: 2011
• 作者: Seong Ki-Hyeon;石井俊輔
• 通讯作者: 石井俊輔

Dampening of death pathways by schnurri-2 is essential for T-cell development.

• DOI: 10.1038/nature09848
• 发表时间: 2011-04-07
• 期刊: NATURE
• 影响因子: 64.8
• 作者: Staton, Tracy L.;Lazarevic, Vanja;Jones, Dallas C.;Lanser, Amanda J.;Takagi, Tsuyoshi;Ishii, Shunsuke;Glimcher, Laurie H.
• 通讯作者: Glimcher, Laurie H.

ATF-7は炎症の抑制因子として機能する

ATF-7 具有炎症抑制剂的作用

• 发表时间: 2011
• 作者: 中山北斗;木村成介;吉田圭介
• 通讯作者: 吉田圭介