Regulation of alternative splicing in response to heat-stress

响应热应激的选择性剪接调节

• 批准号: 24657118
• 负责人: INOUE Kunio
• 金额: $ 2.58万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24657118/
• 关键词: 遺伝子; 発現制御; 細胞環境; スプライシング

It is known that RNA splicing is repressed in response to heat-stress. Here we examined if the U1 snRNP-independent splicing plays a role in efficient splicing of hsp genes under heat condition. Moreover, we identified an RNA-binding protein required for induction of alternative splicing of hsp105 in response to heat-stress.

已知RNA剪接响应于热应激而被抑制。在这里，我们检查是否U1 snRNP非依赖性剪接在热条件下热休克蛋白基因的有效剪接中起作用。此外，我们确定了一个RNA结合蛋白诱导热应激反应的热休克蛋白105的选择性剪接。

项目成果

A specific set of EJC subunits is required for the nuclear retention of unspliced RNAs in C. elegans

秀丽隐杆线虫中未剪接 RNA 的核保留需要一组特定的 EJC 亚基

• DOI: 10.1128/mcb.01298-12
• 发表时间: 2013
• 期刊: Molecular and Cellular Biology
• 影响因子: 5.3
• 作者: Masami Shiimori;KunioInoue;Hiroshi Sakamoto
• 通讯作者: Hiroshi Sakamoto