Relationship between lipid droplets and peroxisomes through the mitochondria-associated ER membrane

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We examined whether the MAM (mitochondria-associated membrane), a subdomain of the endoplasmic reticulum, participates in lipid droplet formation and peroxisome biogenesis. Lipid droplet formation was suppressed by knockdown of MAM-organizing proteins, such as syntaxin17. Rab32 may also contribute to lipid droplet formation. Depletion of Sec16B caused lipid droplet formation and elongation of peroxisomes in a certain cell type, but suppressed lipid droplet formation and shortened peroxisomes in another type of cells. The data suggest that the MAM has an important role in lipid droplet formation, and that there is an intimate relation between lipid droplet formation and peroxisome biogenesis.