Discovery of new function of organophosphorus compounds and their applications to catalytic asymmetric synthesis
有机磷化合物新功能的发现及其在催化不对称合成中的应用
基本信息
- 批准号:24659002
- 负责人:
- 金额:$ 2.41万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Challenging Exploratory Research
- 财政年份:2012
- 资助国家:日本
- 起止时间:2012-04-01 至 2014-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We focused on phosphide compounds like a sulfonamide as a precursor of an anionic ligand, which have never been reported to date. We first examined the reaction of phenyl phosphine. But no phosphide was obtained. Then, we examined the experiments to corroborate the known procedure using diphenylphosphine and tosyl chloride. Surprisingly, we obtained tolylthiooxydiphenylphosphine oxide instead of the expected phosphide. Based on the results, we re-examined the reaction of phenylphosphine with tosyl chloride, which afforded phenylthiophosphonic acid phenyl thioester. Interestingly, this reaction is a completely new reaction through disproportionation reaction between sulfur and phosphorus. Next, we focused on the reaction of phenyl phosphine with acylating agents. When phosphine borane instead of phosphine, the desired phosphide was isolated as a borane complex. Now we are examining the removal of the borane from the product.
我们专注于磷化合物,如磺酰胺作为阴离子配体的前体,这是迄今为止从未报道过的。我们首先考察了苯基膦的反应。但没有得到磷化物。然后,我们检查了实验以证实使用二苯基膦和甲苯磺酰氯的已知程序。令人惊讶的是,我们获得了甲苯基硫代氧基二苯基氧化膦,而不是预期的磷化物。在此基础上,我们重新考察了苯基膦与对甲苯磺酰氯的反应,得到了苯硫代膦酸苯硫酯。有趣的是,该反应是一个全新的反应,通过硫和磷之间的反硝化反应。接下来,我们重点研究了苯基膦与酰化剂的反应。当膦硼烷代替膦时,所需的磷化物作为硼烷络合物分离。现在我们正在研究从产品中除去硼烷。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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HAMADA Yasumasa其他文献
HAMADA Yasumasa的其他文献
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{{ truncateString('HAMADA Yasumasa', 18)}}的其他基金
Development of highly efficient synthetic processes and their applications to natural products
高效合成工艺的开发及其在天然产物中的应用
- 批准号:
23390003 - 财政年份:2011
- 资助金额:
$ 2.41万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development of catalytic methods in organic synthesis and their applications to the synthesis of biologically interesting natural products
有机合成催化方法的发展及其在合成具有生物学意义的天然产物中的应用
- 批准号:
19390003 - 财政年份:2007
- 资助金额:
$ 2.41万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development of Transition-metal Catalysts and Their Applications to Asymmetric Catalysis
过渡金属催化剂的发展及其在不对称催化中的应用
- 批准号:
17390004 - 财政年份:2005
- 资助金额:
$ 2.41万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development of Rigid Tricyclic Ligands and their Application to Asymmetric Catalysis
刚性三环配体的开发及其在不对称催化中的应用
- 批准号:
13470467 - 财政年份:2001
- 资助金额:
$ 2.41万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Synthesis of Cell-cycle Inhibitory Peptides and Their Development for Medicinal Use
细胞周期抑制肽的合成及其药用开发
- 批准号:
11557171 - 财政年份:1999
- 资助金额:
$ 2.41万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Design and development of monodentate chiral phosphines and their applications to asymmetric synthsese
单齿手性膦的设计、开发及其在不对称合成中的应用
- 批准号:
09470480 - 财政年份:1997
- 资助金额:
$ 2.41万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Synthetic Studies on Hennoxazole A with Antivirus Activity
具有抗病毒活性的亨诺恶唑A的合成研究
- 批准号:
06672106 - 财政年份:1994
- 资助金额:
$ 2.41万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
Total Synthesis of Cyclotheonamides, Potent Inhibitors of Thrombin
凝血酶强效抑制剂环草酰胺的全合成
- 批准号:
04671303 - 财政年份:1992
- 资助金额:
$ 2.41万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
オキサソール環の構築、開裂反応を基盤とする生理活性物質の合成研究
基于恶唑环的构建和裂解反应合成生理活性物质的研究
- 批准号:
62570948 - 财政年份:1987
- 资助金额:
$ 2.41万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)