Development of catalytic methods in organic synthesis and their applications to the synthesis of biologically interesting natural products

发展有机合成中的催化制备方法是绿色化学的需要。我们一直致力于开发过渡金属催化的不对称合成和有机催化不对称合成，并将它们应用于具有生物意义的天然产物。我们成功地开发了Ru、Ir和Ni催化的β-羟基-α-氨基酸酯的不对称合成。此外，我们使用我们的方法研究了钯和新的单齿磷配体的不对称烯丙基烷基化反应以及吲哚生物碱唐古托林的全合成。此外，我们还开展了以α，α-二苯基脯氨醇O-三乙基硅基醚为有机催化剂的四氢喹啉和氮杂环丙烷的不对称合成，并成功地合成了缓激肽受体拮抗剂马丁内林。

The development of catalytic preparation methods in organic synthesis is desirable for green chemistry. We have been working on the development of transition-metal-catalyzed asymmetric synthesis and organocatalytic asymmetric synthesis and their applications to biologically interesting natural products. We have succeeded in the development of the ruthenium-, iridium-, and nickel-catalyzed asymmetric synthesis of β-hydroxy-α-amino acid esters. In addition, we investigated asymmetric allylic alkylation using the combination of palladium and new monodentate phosphorus ligands and the total synthesis of tangutorine, an indole alkaloid, using our method. Furthermore, we developed the asymmetric synthesis of tetrahydroquinolines and aziridines using α,α-diphenylprolinol O-triethylsilyl ether as the organocatalyst and succeeded in the asymmetric synthesis of martinelline, a bradykinin receptor antagonist, using our method.