Development of catalytic methods in organic synthesis and their applications to the synthesis of biologically interesting natural products

有机合成中催化剂制备方法的发展是绿色化学发展的需要。我们一直致力于发展过渡金属催化的不对称合成和有机催化的不对称合成及其在生物活性天然产物中的应用。我们成功地发展了钌、铱和镍催化的β-羟基-α-氨基酸酯的不对称合成。此外，我们研究了不对称烯丙基烷基化使用钯和新的单齿磷配体的组合和全合成唐古托碱，吲哚生物碱，使用我们的方法。在此基础上，我们发展了以α，α-二苯基脯氨醇O-三乙基硅醚为催化剂的四氢喹啉和氮杂环丙烷的不对称合成，并成功地合成了缓激肽受体拮抗剂martinelline。

The development of catalytic preparation methods in organic synthesis is desirable for green chemistry. We have been working on the development of transition-metal-catalyzed asymmetric synthesis and organocatalytic asymmetric synthesis and their applications to biologically interesting natural products. We have succeeded in the development of the ruthenium-, iridium-, and nickel-catalyzed asymmetric synthesis of β-hydroxy-α-amino acid esters. In addition, we investigated asymmetric allylic alkylation using the combination of palladium and new monodentate phosphorus ligands and the total synthesis of tangutorine, an indole alkaloid, using our method. Furthermore, we developed the asymmetric synthesis of tetrahydroquinolines and aziridines using α,α-diphenylprolinol O-triethylsilyl ether as the organocatalyst and succeeded in the asymmetric synthesis of martinelline, a bradykinin receptor antagonist, using our method.