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Mechanistic analysis of hand-foot syndrome associated with kinase inhibitors

Mechanistic analysis of hand-foot syndrome associated with kinase inhibitors
激酶抑制剂相关手足综合征的机制分析
批准号：
24659069
负责人：
SUZUKI Hiroshi
金额：
$2.5万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Challenging Exploratory Research
财政年份：
2012
资助国家：
日本
项目状态：
已结题
起止时间：
2012-04-01 至 2014-03-31
来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659069/
关键词：
薬剤反応性薬理学シグナル伝達癌生体分子

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中文摘要
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英文摘要
Hand-foot syndrome is an adverse reaction frequently observed in patients administering some tyrosine kinase inhibitors (TKIs), which sometimes becomes too severe to continue the therapy. Although we had originally hypothesized that the syndrome is caused by a single inhibition of FLT3, this hypothesis turned out to be implausible when we considered the information of newly developed TKIs which became available after the start of this research. Analyses based on currently up to date information have suggested that VEGR inhibition is a common factor for the syndrome and that simultaneous inhibitions of CSF1R and VEGFR suppress the onset. On the other hand, FLT3 inhibition was considered to negate the suppressive effect against the onset which could be achieved by CSF1R inhibition.
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