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Mechanism analysis of abacavir hypersensitivity

Mechanism analysis of abacavir hypersensitivity
阿巴卡韦过敏机制分析
批准号：
22659029
负责人：
SUZUKI Hiroshi
金额：
$2.02万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Challenging Exploratory Research
财政年份：
2010
资助国家：
日本
项目状态：
已结题
起止时间：
2010 至 2011
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659029/
关键词：
薬剤反応性特異体質性毒性プロテオーム免疫応答HLAアバカビル生体分子薬理学

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中文摘要
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英文摘要
In abacavir hypersensitivity associated with HLA-B* 5701 genecareers, it is strongly suggested that the causal antigen is not peptides derived from protein adducts, as is assumed previously, but the abacavir itself. In the other cases caused by the same mechanism with abacavir hypersensitivity, the existing screening system based on the amount of protein adducts formation cannot find out the risk of adverse effect. The combination with the new screening system to discriminate if the drugs or their metabolites are presented as antigen will improve the prediction accuracy of idiosyncraticadverse effect
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