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Development of new therapies for tumor and autoimmunity using CD8aaT cells

Development of new therapies for tumor and autoimmunity using CD8aaT cells
使用 CD8aaT 细胞开发肿瘤和自身免疫的新疗法
批准号:
24659148
负责人:
SUGAI Manabu
金额:
$2.5万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31

项目摘要

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中文摘要
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英文摘要
Cell fate determination of helper T cells (CD4 T cells) or cytotoxic T cells (CD8 T cells) is mutually exclusive process depending on antigen recognition, which occurs in the thymus. We found that retinoic acid and transforming growth factor-b1 promoted the differentiation of CD8 aaT cells from CD4 T cells in peripheral lymphoid tissues. And we examined the expression patterns of various genes in differentiated CD8aa T cells and compared with those in iTreg cells. Furthermore, we found various compounds, which regulate differentiation of CD8aa T cells from CD4 cells.
期刊论文(21)
专著(0)
科研奖励(0)
会议论文
Id2 controls chondrogenesis acting downstream of BMP signaling during maxillary morphogenesis
Id2 在上颌形态发生过程中控制软骨形成,作用于 BMP 信号下游
DOI: --
发表时间: 2012
期刊: Bone
影响因子: 4.1
作者: [Sakata-Goto, T., Takahashi, K., Kiso, H., Huang, B., Tsukamoto, H., Takemoto, M., Hayashi, T., Sugai, M., Nakamura, T., Yokota, Y., Shimizu, A., Slavkin, H., Bessho, K.]
通讯作者: K.
制御性T細胞と大腸炎関連派発癌GI
调节性 T 细胞和结肠炎相关的致癌胃肠道
DOI: --
发表时间: 2012
期刊: Research
影响因子: 11
作者: [菅井学, 南部由希子, 清水章]
通讯作者: 清水章
Phenotypes of CCAAT/enhancer-binding protein beta deficiency : hyperdontia
CCAAT/增强子结合蛋白β缺陷的表型:多牙症
DOI: --
发表时间: 2013
期刊: Oral Diseases
影响因子: 3.8
作者: [Huang, B., Takahashi, K., Sakata-Goto, T., Kiso, H., Togo, Y., Saito, K., Tsukamoto, H., Sugai, M., Shimizu, A. and Bessho, K.]
通讯作者: K.
DOI: 10.1038/srep00642
发表时间: 2012
期刊: SCIENTIFIC REPORTS
影响因子: 4.6
作者: [Nambu, Yukiko, Hayashi, Tatsunari, Jang, Kyoung-Jin, Aoki, Koji, Mano, Hiroto, Nakano, Keiko, Osato, Motomi, Takahashi, Katsu, Itoh, Katsuhiko, Teramukai, Satoshi, Komori, Toshihisa, Fujita, Jun, Ito, Yoshiaki, Shimizu, Akira, Sugai, Manabu]
通讯作者: Sugai, Manabu
11
    Analysis of the functional difference among various Id proteins
    • 批准号:
      21590307
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.0万
    • 财政年份:
      2009
    • 负责人:
      SUGAI Manabu
    • 依托单位:
    Molecular analysis of ANKH toward gene therapy for TMD
    • 批准号:
      17592073
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.24万
    • 财政年份:
      2005
    • 负责人:
      SUGAI Manabu
    • 依托单位:
    Regulation of the Class Switch Recombination
    • 批准号:
      16590226
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.3万
    • 财政年份:
      2004
    • 负责人:
      SUGAI Manabu
    • 依托单位:
    The roles of E2A and Id2 in class switch recombination
    • 批准号:
      14570104
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.86万
    • 财政年份:
      2002
    • 负责人:
      SUGAI Manabu
    • 依托单位:
    海外基金