Molecular analysis of ANKH toward gene therapy for TMD

ANKH 对 TMD 基因治疗的分子分析

• 批准号: 17592073
• 负责人: SUGAI Manabu
• 金额: $ 2.24万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17592073/
• 关键词: tooth regenaration; USAG-1; diphyodont; polymorphism

(A) Analysis of ank(progressive ankylosis) mouseThe TMJ(temporomandibular join)t of ank mouse was observed in one, two, three, four, five and six months. Mild synovitis was shown in TMJ, while severe ankylosis in other joints. Arthritis in TMJ was demonstrated in ank mouse.(B) Polymorphic analysis of ANKH gene in TMD(temporomandibular disorder) patientsHuman gene analysis in inTMD patients was approved by the medical ethics committee of Kyoto University on December 9, 2001 (#G86). As to ANK-OR and ANK-TR, which were recently reported (Florence WL, 2003) case-control study was done in about 80 cases. These involved clicking (16 cases), intermittent lock(13 cases) and closed lock (36 cases).

观察1、2、3、4、5、6个月时ANK小鼠的TMJ(TMJ)。TMJ表现为轻度滑膜炎症，其他关节表现为重度强直。(B)颞下颌关节紊乱病(TMD)患者Ankh基因的多态性分析2001年12月9日京都大学医学伦理学委员会批准对TMD患者进行人类基因分析(#g86)。对最近报道的ANK-OR和ANK-TR(Florence WL，2003)进行了病例对照研究。其中点击16例，间歇性锁定13例，闭合性锁定36例。

项目成果

Polymorphisms in PTCH1 affect the risk of Amelblastoma

PTCH1 的多态性影响成釉细胞瘤的风险

• 发表时间: 2005
• 期刊: J.Dent.Res 84
• 作者: Kawabata;T.;Takahashi;K.;Sugai;M.;Murashima-Suginami;A.;Ando;S.;Shumizu;A.;Kosugi;S.;Sato;T.;Nishida;M.;Murakami;K.and Iizuka;T.
• 通讯作者: T.

Polymorphisms in PTCH1 affect the risk of ameloblastoma

• DOI: 10.1177/154405910508400906
• 发表时间: 2005-09-01
• 期刊: JOURNAL OF DENTAL RESEARCH
• 影响因子: 7.6
• 作者: Kawabata, T;Takahashi, K;Iizuka, T
• 通讯作者: Iizuka, T

Germline mutations of the PTCH gene in Japanese patients with nevoid basal cell carcinoma syndrome

• DOI: 10.1007/s00403-004-0520-1
• 发表时间: 2005-01-01
• 期刊: ARCHIVES OF DERMATOLOGICAL RESEARCH
• 影响因子: 3
• 作者: Tanioka, M;Takahashi, K;Iizuka, T
• 通讯作者: Iizuka, T

Rudiment incisors survive and erupt as supernumerary teeth as a result of USAG-1 abrogation

• DOI: 10.1016/j.bbrc.2007.05.148
• 发表时间: 2007-08-03
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Murashima-Suginami, Akiko;Takahashi, Katsu;Bessho, Kazuhisa
• 通讯作者: Bessho, Kazuhisa

Enhanced BMP signaling results in supernumerary tooth formation in USAG-1 dificient mouse

增强的 BMP 信号传导导致 USAG-1 缺陷小鼠形成多生牙

• 发表时间: 2008
• 期刊: Biochem Biophys Res Commun (In press)
• 作者: Akiko Murashima-Suginami;Katsu Takahashi;Tomoko Sakata;Hiroko Tsukamoto;Manabu Sugai;Motoko Yanagita;Akira Shimizu;Takeshi Sakurai;Harold C.Slavkin and kazuhisa Bessho
• 通讯作者: Harold C.Slavkin and kazuhisa Bessho